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260 Newest Publications in genes to cells
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FASTER: an unsupervised fully automated sleep staging method for mice
29-04-2013 | Genshiro A. Sunagawa, Hiroyoshi Séi, Shigeki Shimba, Yoshihiro Urade, Hiroki R. Ueda, Genes to Cells, 2013
Identifying the stages of sleep, or sleep staging, is an unavoidable step in sleep research and typically requires visual inspection of electroencephalography (EEG) and electromyography (EMG) data. Currently, scoring is slow, biased and prone to error by humans and thus is the most ...
Interaction of Necl‐4/CADM4 with ErbB3 and integrin α6β4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly
24-04-2013 | Hirokazu Sugiyama, Kiyohito Mizutani, Souichi Kurita, Naomasa Okimoto, Yohei Shimono, Yoshimi Takai, Genes to Cells, 2013
Nectin‐like molecule 4 (Necl‐4)/CADM4, a transmembrane cell–cell adhesion molecule with three Ig‐like domains, was shown to serve as a tumor suppressor, but its mode of action has not been elucidated. In this study, we showed that Necl‐4 interacted in cis with ErbB3 through their ...
CaMKIIβ‐mediated LIM‐kinase activation plays a crucial role in BDNF‐induced neuritogenesis
19-04-2013 | Akihiko Saito, Ken Miyajima, Junichi Akatsuka, Hiroshi Kondo, Toshiya Mashiko, Tai Kiuchi, Kazumasa Ohashi, Kensaku ..., Genes to Cells, 2013
LIM‐kinase 1 (LIMK1) regulates actin cytoskeletal reorganization by phosphorylating and inactivating actin‐depolymerizing factor and cofilin. We examined the role of LIMK1 in brain‐derived neurotrophic factor (BDNF)‐induced neuritogenesis in primary‐cultured rat cortical neurons. Knockdown ...
Angiotensin II‐induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16
19-04-2013 | Emi Matsumoto, Sayaka Sasaki, Hideyuki Kinoshita, Takuya Kito, Hiroya Ohta, Morichika Konishi, Koichiro Kuwahara, Ka ..., Genes to Cells, 2013
Fibroblast growth factors (Fgfs) are pleiotropic proteins involved in development, repair and metabolism. Fgf16 is predominantly expressed in the heart. However, as the heart function is essentially normal in Fgf16 knockout mice, its role has remained unclear. To elucidate the ...
Efficient identification of TALEN‐mediated genome modifications using heteroduplex mobility assays
11-04-2013 | Satoshi Ota, Yu Hisano, Michiko Muraki, Kazuyuki Hoshijima, Timothy J. Dahlem, David J. Grunwald, Yasushi Okada, Ats ..., Genes to Cells, 2013
The heteroduplex mobility assay (HMA) is widely used to characterize strain variants of human viruses. To determine whether it can detect small sequence differences in homologous templates, we constructed a series of deletion constructs (1–10bp deletions) in the multiple cloning site (MCS) ...
System to quantify the import of peroxisomal matrix proteins by fluorescence intensity
11-04-2013 | Masafumi Noguchi, Kanji Okumoto, Yukio Fujiki, Genes to Cells, 2013
Fourteen distinct peroxins are essential for peroxisome biogenesis in mammals, of which ten are involved in the import of matrix proteins into peroxisomes. Peroxisomal matrix protein import is regulated by various cellular factors; however, the mechanisms underlying this regulation are ...
Mitochondrial localization of the antiviral signaling adaptor IPS‐1 is important for its induction of caspase activation
11-04-2013 | Tomohiko Okazaki, Maiko Higuchi, Yukiko Gotoh, Genes to Cells, 2013
The RIG‐I‐like receptor (RLR) family of intracellular receptors detects viral nucleic acids and transmits an antiviral signal through the adaptor IPS‐1. IPS‐1 activation triggers host defense mechanisms, including rapid production of type I interferon (IFN), such as IFN‐β, and induction of ...
WNK4 is an essential effector of anterior formation in FGF signaling
21-03-2013 | Masahiro Shimizu, Toshiyasu Goto, Atsushi Sato, Hiroshi Shibuya, Genes to Cells, 2013
With no lysine (K) (WNK) kinase family is conserved among many species and regulates SPAK/OSR1 and ion cotransporters. WNK is also involved in developmental and cellular processes, but the molecular mechanisms underlying its regulation in these processes remain unknown. In this study, we ...
Phosphorylation of a conserved Thr357 in yeast Nedd4‐like ubiquitin ligase Rsp5 is involved in down‐regulation of the general amino acid permease Gap1
21-03-2013 | Toshiya Sasaki, Hiroshi Takagi, Genes to Cells, 2013
Rsp5, an essential HECT‐type ubiquitin ligase, is the only yeast Saccharomyces cerevisiae member of the Nedd4 family. Rsp5 triggers the ubiquitination‐dependent endocytosis of the general amino acid permease Gap1 in response to a good nitrogen source. Previously, we showed that the ...
Identification of small subunit of serine palmitoyltransferase a as a lysophosphatidylinositol acyltransferase 1‐interacting protein
20-03-2013 | Yusuke Hirata, Natsumi Yamamori, Nozomu Kono, Hyeon‐Cheol Lee, Takao Inoue, Hiroyuki Arai, Genes to Cells, 2013
Lysophosphatidylinositol acyltransferase 1 (LPIAT1), also known as MBOAT7, is a phospholipid acyltransferase that selectively incorporates arachidonic acid (AA) into the sn‐2 position of phosphatidylinositol (PI). We previously demonstrated that LPIAT1 regulates AA content in PI and plays a ...
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