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575 Newest Publications in european journal of clinical pharmacology
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Drug use in patients with dementia: a register-based study in the health region of Girona (Catalonia/Spain)
26-11-2012 | Pilar Àvila-Castells, Josep Garre-Olmo, Laia Calvó-Perxas, Oriol Turró-Garriga, Elisabet Alsina, Olga Carmona, Hécto ..., European Journal of Clinical Pharmacology, 2012
Purpose To describe the pattern of drug consumption among patients with dementia in a geographically defined general population in Catalonia (Spain), and to determine its association with age, gender, type of dementia and severity indicators. Methods Cross-sectional study that included 1,894 ...
A review of the potential protective effects of pentoxifylline against drug-induced nephrotoxicity
26-11-2012 | Zahra Nasiri-Toosi, Simin Dashti-Khavidaki, Hossein Khalili, Mahboob Lessan-Pezeshki, European Journal of Clinical Pharmacology, 2012
Purpose Drug-induced nephrotoxicity is one of the most common side effects of medications and accounts for about 20 % of hospital admissions for acute kidney injury (AKI). Some possible pharmacologic mechanisms of pentoxifylline (PTX) that suggest it as a candidate to ameliorate AKI include ...
A phase I study to assess the single and multiple dose pharmacokinetics of THC/CBD oromucosal spray
26-11-2012 | C. G. Stott, L. White, S. Wright, D. Wilbraham, G. W. Guy, European Journal of Clinical Pharmacology, 2012
Purpose A Phase I study to assess the single and multipledose pharmacokinetics (PKs) and safety and tolerability of oromucosally administered Δ9-tetrahydrocannabinol (THC)/cannabidiol (CBD) spray, an endocannabinoid system modulator, in healthy male subjects. Methods Subjects received either ...
Gamma-hydroxybutyrate (GHB) and topiramate—clinically relevant drug interaction suggested by a case of coma and increased plasma GHB concentration
19-11-2012 | Tobias Weiss, Daniel Müller, Isabelle Marti, Caroline Happold, Stefan Russmann, European Journal of Clinical Pharmacology, 2012
Gamma-hydroxybutyrate (GHB) and topiramate—clinically relevant drug interaction suggested by a case of coma and increased plasma GHB concentration Content Type Journal Article Category Letter to the Editors Pages 1-2 DOI 10.1007/s00228-012-1450-z Authors Tobias Weiss, Department ...
Calcium bioavailability of calcium L-threonate in healthy Chinese subjects measured with stable isotopes (44Ca and 42Ca)
15-11-2012 | Hongyun Wang, Pei Hu, Ji Jiang, European Journal of Clinical Pharmacology, 2012
Purpose Calcium L-threonate is a novel drug that was developed for the treatment of osteoporosis and as a calcium supplement. However, calcium bioavailability of this drug is unknown due to lack of effective evaluation methods. In this study, we sought to measure the bioavailability of ...
Effect of the CYP2C19*2 and *3 genotypes, ABCB1 C3435T and PON1 Q192R alleles on the pharmacodynamics and adverse clinical events of clopidogrel in Chinese people after percutaneous coronary intervention
13-11-2012 | Xiao-Fang Tang, Jing Wang, Jia-Hui Zhang, Xian-Min Meng, Bo Xu, Shu-Bin Qiao, Yong-Jian Wu, Jue Chen, Yuan Wu, Ji-Li ..., European Journal of Clinical Pharmacology, 2012
Purpose Chinese people are more frequent carriers of cytochrome P450 2C19 (CYP2C19) loss-of-function alleles than Caucasians. The effect of the ATP-binding cassette, sub-family B, member 1 (ABCB1), and paraoxonase 1 (PON1) variants on platelet reactivity and clinical outcomes of clopidogrel ...
NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: A randomized controlled trial for pharmacogenetics-based therapy
13-11-2012 | Junichi Azuma, Masako Ohno, Ryuji Kubota, Soichiro Yokota, Takayuki Nagai, Kazunari Tsuyuguchi, Yasuhisa Okuda, Tets ..., European Journal of Clinical Pharmacology, 2012
Objective This study is a pharmacogenetic clinical trial designed to clarify whether the N-acetyltransferase 2 gene (NAT2) genotype-guided dosing of isoniazid improves the tolerability and efficacy of the 6-month four-drug standard regimen for newly diagnosed pulmonary tuberculosis. Methods ...
Personalizing antiplatelet therapy-moving to clinics
13-11-2012 | Subraja Kumaresan, Steven Dkhar, European Journal of Clinical Pharmacology, 2012
Personalizing antiplatelet therapy-moving to clinics Content Type Journal Article Category Letter to the Editors Pages 1-1 DOI 10.1007/s00228-012-1445-9 Authors Subraja Kumaresan, Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research ...
Serial CSF sampling over a period of 30 h via an indwelling spinal catheter in healthy volunteers: headache, back pain, tolerability and measured acetylcholine profile
09-11-2012 | Izaak den Daas, Johan Wemer, Khalid Abou Farha, Wim Tamminga, Theo de Boer, Rob Spanjersberg, Michel M. R. F. Struys ..., European Journal of Clinical Pharmacology, 2012
Background/aim Timed interval cerebrospinal fluid (CSF) sampling by indwelling catheterization can be a valuable corroborative tool for the pharmacokinetic and pharmacodynamic assessment of drugs. CSF sampling in studies on drug candidates for Alzheimer’s disease have been conducted in ...
Categorising paediatric prescribing errors by junior doctors through prescribing competency assessment: does assessment reflect actual practice?
09-11-2012 | Tessa Davis, Hong Thoong, Anna Kelsey, Guy Makin, European Journal of Clinical Pharmacology, 2012
Purpose It is recognised that paediatric prescribing errors are prevalent, and that most are made by junior doctors; however, detecting errors in order to demonstrate actual error rates can be difficult. There is evidence to suggest that dosing errors are the most common type of prescribing ...
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