16-04-2013 | D. Ryan, A. Atik, R. De Matteo, R. Harding, M.J. Black, Clinical and Experimental Pharmacology and Physiology, 2013

Summary A reduced nephron endowment early in life adversely impacts on long‐term functional reserve in the kidney. A recent study has shown that acute exposure to chorioamnionitis during late gestation can adversely impact on nephrogenesis. The present study aimed to examine the effects ...

more

16-04-2013 | Chang‐Qing XU, Clinical and Experimental Pharmacology and Physiology, 2013

During the preparation of our paper published in your journal in 2010,1 the actin loading control blots shown in Figure 1 (a) and (b) were mixed up and the same acting control blot was used in error. By this letter, I would like to assure you and the readers that the correct loading ...

more

16-04-2013 | Chris Reid, Clinical and Experimental Pharmacology and Physiology, 2013

Abstract Cardiovascular disease rates have declined considerably over the past 40 years but remain a major contributor to the disease burden in Australia. With major increases in the number of people reaching their 7th and 8th decade of life and increases in the prevalence and incidence ...

more

12-04-2013 | Linda A. Gallo, Melanie Tran, Karen M. Moritz, Mary E. Wlodek, Clinical and Experimental Pharmacology and Physiology, 2013

Summary Suboptimal conditions in utero are associated with the development of adult‐onset diseases in offspring. Uteroplacental insufficiency in rats is a well‐established animal model used to mimic and study the effects of developmental insults relevant to countries of abundant ...

more

09-04-2013 | Kei Asayama, Rudolph Schutte, Yan Li, Tine W Hansen, Jan A Staessen, Clinical and Experimental Pharmacology and Physiology, 2013

Summary In this mini‐review, we will address the predictive value of blood pressure variability, over and beyond level of pressure, in randomly selected population samples. All reviewed studies had sufficient power, long follow‐up duration and a wide age range. We assessed blood ...

more

09-04-2013 | Thaiana C.F. Mendes, Fernanda Antunes, Margarete M. Trachez, Nailton M Nascimento, Carlos A.M Fraga, Eliezer J. Barr ..., Clinical and Experimental Pharmacology and Physiology, 2013

Summary New chemicals or adjuvants with analgesic effects on chronic pain are needed and clinically relevant due to the limited number of effective compounds which possess these characteristics. LASSBio‐873, a pyrazolo[3,4‐b]pyrrolo[3,4‐d]pyridine derivative, activates muscarinic ...

more

09-04-2013 | Yu‐Hsun Kao, Yao‐Chang Chen, Chen‐Chih Chung, Gi‐Shih Lien, Shih‐Ann Chen, Ching‐Chuan Kuo, Yi‐Jen Chen, Clinical and Experimental Pharmacology and Physiology, 2013

Summary Heart failure (HF) can increase atrial fibrillation and induce cardiac hypermethylation. Pitx2c plays important roles in the genesis of atrial fibrillation and the promoter region of Pitx2c contains CpG islands. Therefore, epigenetic modification by hypermethylation may reduce ...

more

05-04-2013 | Virginia Ip, Johnson J. Liu, Mark J. McKeage, Clinical and Experimental Pharmacology and Physiology, 2013

Summary The purpose of this study was to determine whether copper histidine could inhibit Ctr1‐mediated transport of oxaliplatin in vitro, and thereby limit the accumulation of platinum and neurotoxicity of oxaliplatin in dorsal root ganglion (DRG) tissue in vivo. In HEK293 cells ...

more

30-03-2013 | Helena M Viola, Livia C Hool, Clinical and Experimental Pharmacology and Physiology, 2013

Summary The L‐type Ca2+ channel is the main route for Ca2+ entry into cardiac myocytes, which is essential for the maintenance of cardiac excitation and contraction. Alterations in L‐type Ca2+ channel activity and Ca2+ homeostasis have been implicated in the development of ...

more

30-03-2013 | Koh Nakayama, Masaomi Nangaku, Clinical and Experimental Pharmacology and Physiology, 2013

See original article on page 262

more