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435 Newest Publications in clinical and experimental pharmacology and physiology
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Non‐invasive cardiovascular profiling using combined electrocardiogram‐Doppler ultrasonography and impedance cardiography: an experimental approach
04-05-2013 | Kathleen Tomsin, Annette Vriens, Tinne Mesens, Wilfried Gyselaers, Clinical and Experimental Pharmacology and Physiology, 2013
Summary In this experimental study, the feasibility of cardiovascular profiling using both combined electrocardiogram (ECG)‐Doppler ultrasonography and impedance cardiography (ICG) is evaluated. Fourteen non‐pregnant healthy women received 500 mL of saline solution (NaCl 0.9% at 999 ...
Ventricular repolarization in a rat model of global heart failure
04-05-2013 | Valeria Krandycheva, Sergey Kharin, Marina Strelkova, Konstantin Shumikhin, Aleksey Sobolev, Dmitry Shmakov, Clinical and Experimental Pharmacology and Physiology, 2013
Summary Isoproterenol in high doses induces infarction‐like myocardial damage, and structural and functional remodelling of ventricular myocardium. The purpose of this study was to investigate ventricular repolarization in a rat model of isoproterenol‐induced heart ...
Automated measurement of office, home and ambulatory blood pressure in atrial fibrillation
04-05-2013 | Anastasios Kollias, George S. Stergiou, Clinical and Experimental Pharmacology and Physiology, 2013
Summary Hypertension and atrial fibrillation (AF) often coexist and are strong risk factors for stroke. Current guidelines for blood pressure (BP) measurement in AF recommend repeated measurements using the auscultatory method, whereas the accuracy of the automated devices is regarded ...
Caption: The molecular machinery mediating store‐operated calcium entry in skeletal muscle. See Cully and Launikonis pp. 338‐344.
25-04-2013 | Clinical and Experimental Pharmacology and Physiology, 2013
Cover image: The molecular machinery mediating store‐operated calcium entry in skeletal muscle. See Cully and Launikonis pp. 338‐344. Molecular targets in antimetastatic therapy Drug–drug and drug–disease interactions in older people Genetic polymorphisms and ...
Pre‐stem cell formation by non‐platelet RNA‐containing particle fusion
23-04-2013 | Wuyi Kong, Mu Nuo, Xiao Ping Zhu, Xiu Juan Han, Lihua Luo, Xian Wang, Clinical and Experimental Pharmacology and Physiology, 2013
Summary We found a group of non‐platelet RNA‐containing particles (NPRCPs) in human umbilical cord blood. To understand the origin, characterization and differentiation of NPRCPs, we examined cord blood‐isolated NPRCPs in vitro. NPRCPs are from Our data provide strong evidence that ...
Diffuse traumatic brain injury and the sensory brain
23-04-2013 | Dasuni S Alwis, Victoria Johnstone, Edwin Yan, Ramesh Rajan, Clinical and Experimental Pharmacology and Physiology, 2013
Summary In this review, we discuss the consequences to the brain's cortex, specifically to the sensory cortex, of traumatic brain injury. The thesis underlying this approach is that long‐term deficits in cognition seen after brain damage in humans are likely underpinned by an impaired ...
A high‐fat diet and multiple administration of carbon tetrachloride induces liver injury and pathological features associated with non‐alcoholic steatohepatitis in mice
23-04-2013 | Norihiro Kubota, Shoichi Kado, Mitsuyoshi Kano, Norie Masuoka, Yuriko Nagata, Toshihide Kobayashi, Kouji Miyazaki, F ..., Clinical and Experimental Pharmacology and Physiology, 2013
Summary We aimed to establish a progressive steatohepatitis mouse model as few reported animal models of non‐alcoholic steatohepatitis (NASH) show the progression from fatty liver to steatohepatitis. C57BL/6N mice were fed a high‐fat diet (HFD) to develop obesity and were subsequently ...
Brain And Retinal Microglia In Health And Disease: An Unrecognized Target Of The Renin‐Angiotensin System
20-04-2013 | Claudia A. McCarthy, Robert E. Widdop, Devy Deliyanti, Jennifer L. Wilkinson‐Berka, Clinical and Experimental Pharmacology and Physiology, 2013
Summary Microglia are the resident immune cells within the brain and retina, commonly known as the macrophages of the central nervous system (CNS).1 Microglia survey the surrounding milieu to eliminate invading microbes, clear cellular debris and enforce programmed cell death by ...
Ticagrelor: positive, negative and misunderstood properties as a new antiplatelet agent
16-04-2013 | Jennifer B. Steiner, Zhenbiao Wu, Jun Ren, Clinical and Experimental Pharmacology and Physiology, 2013
Summary Dual antiplatelet therapy is essential for the management of acute coronary syndrome. In particular, combination therapy using aspirin with a platelet ADP (i.e. P2Y12) receptor inhibitor, such as clopidogrel, prasugrel or, more recently, ticagrelor, has been recommended for ...
Chronic restraint stress induces intestinal inflammation and alters the expression of hexose/lipid transporters
16-04-2013 | Chooi Yeng Lee, Clinical and Experimental Pharmacology and Physiology, 2013
Summary Psychosocial stress is reported to be one of the main causes of obesity. Based on observation in studies that relate stress and gut inflammation to obesity, this study hypothesised that chronic stress via inflammation, alters the expression of nutrient transporters, and ...
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