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160 Newest Publications in cardiovascular toxicology
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Arsenic Trioxide Toxicity in H9c2 Myoblasts—Damage to Cell Organelles and Possible Amelioration with Boerhavia diffusa
19-11-2012 | V. P. Vineetha, A. Prathapan, R. S. Soumya, K. G. Raghu, Cardiovascular Toxicology, 2012
Arsenic trioxide (ATO) has been long used as a chemotherapeutic agent because of its significant anticancer property. Unfortunately, the use of ATO is limited due to its cardiotoxic effects. The present study evaluates the protective property of ethanolic extract of Boerhavia diffusa (BDE) ...
Expression of Glucocorticoid-Induced Leucine Zipper (GILZ) in Cardiomyocytes
23-10-2012 | David C. Aguilar, Josh Strom, Beibei Xu, Kyle Kappeler, Qin M. Chen, Cardiovascular Toxicology, 2012
Glucocorticoids (GCs) are frequently prescribed pharmacological agents most notably for their immunosuppressive effects. Endogenous GCs mediate biological processes such as energy metabolism and tissue development. At the cellular level, GCs bind to the glucocorticoid receptor (GR), a ...
Preventive Effects of Egyptian Sweet Marjoram (Origanum majorana L.) Leaves on Haematological Changes and Cardiotoxicity in Isoproterenol-Treated Albino Rats
10-10-2012 | Gamal Ramadan, Nadia M. El-Beih, Nadia M. S. Arafa, Mai M. Zahra, Cardiovascular Toxicology, 2012
We made an attempt to evaluate/compare the cardioprotective activity of two different doses (50 and 100 mg/kg body weight, given orally for 30 consecutive days) of Egyptian sweet marjoram leaf powder (MLP) and marjoram leaf aqueous extract (MLE) against isoproterenol (ISO)-induced myocardial ...
Terminalia arjuna Improves Cardiovascular Autonomic Neuropathy in Streptozotocin-Induced Diabetic Rats
23-09-2012 | Farah Khaliq, Adila Parveen, Savita Singh, M. Eijaz Hussain, M. Fahim, Cardiovascular Toxicology, 2012
The present study was designed to examine the therapeutic potential of Terminalia arjuna bark extract in improving cardiovascular autonomic neuropathy in Streptozotocin (STZ)-induced diabetic Wistar Albino rats. The baroreflex was evaluated by measuring the changes in heart rate with changes ...
Elevation of Central Arterial Stiffness and Vascular Ageing in Opiate Withdrawal: Cross-sectional and Longitudinal Studies
19-09-2012 | Albert Stuart Reece, Gary Kenneth Hulse, Cardiovascular Toxicology, 2012
The central cardiovascular impacts of clinical opiate withdrawal have not been explored in detail. Pulse Wave Analysis (SphygmoCor) was conducted in healthy controls and opiate-dependent populations. A total of 1,294 patients (69.2 % male) were studied in quintuplicate on 2,089 occasions. ...
Acute Clenbuterol Induces Hypotension, Atrioventricular Block and Cardiac Asystole in the Rabbit
18-09-2012 | Yan Ke, Li-Lan Fu, Xia-Fei Hong, Run Dong, Tian-Ming Xu, Jing-Fei Guo, Yan Liu, Ji-Min Cao, Cardiovascular Toxicology, 2012
Clenbuterol is a long-lasting β-adrenoceptor (β-AR) agonist and was once medicated as a bronchial dilatator, and is also used by body-building enthusiasts and athletes and in livestock breeding because of its anabolic effect on skeletal muscles and ability to promote lipolysis. Though ...
Renin–Angiotensin System Modulates Neurotransmitters in the Paraventricular Nucleus and Contributes to Angiotensin II-Induced Hypertensive Response
12-09-2012 | Jie Qi, Dong-Mei Zhang, Yu-Ping Suo, Xin-Ai Song, Xiao-Jing Yu, Carrie Elks, Yuan-Xi Lin, Yan-Yan Xu, Wei-Jin Zang, ..., Cardiovascular Toxicology, 2012
Angiotensin II (ANG II)-induced inflammatory and oxidative stress responses contribute to the pathogenesis of hypertension. In this study, we determined whether renin–angiotensin system (RAS) activation in the hypothalamic paraventricular nucleus (PVN) contributes to the ANG II-induced ...
The Dual-Targeted HER1/HER2 Tyrosine Kinase Inhibitor Lapatinib Strongly Potentiates the Cardiac Myocyte-Damaging Effects of Doxorubicin
05-09-2012 | Brian B. Hasinoff, Daywin Patel, Xing Wu, Cardiovascular Toxicology, 2012
The anticancer drug lapatinib (Tykerb) is a dual tyrosine kinase inhibitor targeting the HER2 (ERBB2) and EGFR (ERBB1, HER1) pathways that have been shown in clinical trials to display some cardiotoxicity. Because trastuzumab also targets HER2 receptors, the lapatinib/doxorubicin combination ...
Adenosine Transport Blockade Restores Attenuated Cardioprotective Effects of Adenosine Preconditioning in the Isolated Diabetic Rat Heart: Potential Crosstalk with Opioid Receptors
05-09-2012 | Nidhi Krishan Sharma, Nanjaian Mahadevan, Pitchai Balakumar, Cardiovascular Toxicology, 2012
Considering the reduced ability of cardiac fibroblasts to release adenosine and increased ability of interstitial adenosine uptake during diabetes mellitus, the present study investigated the effect of adenosine preconditioning and the existence of cross-talk with opioid receptor activation ...
Cardiovascular Benefits of Black Cumin (Nigella sativa)
22-08-2012 | Adel Shabana, Ayman El-Menyar, Mohammad Asim, Hiba Al-Azzeh, Hassan Al Thani, Cardiovascular Toxicology, 2012
Black Cumin (Nigella sativa), which belongs to the botanical family of Ranunculaceae, commonly grows in Eastern Europe, the Middle East, and Western Asia. Its ripe fruit contains tiny black seeds, known as “Al-Habba Al-Sauda” and “Al-Habba Al-Barakah” in Arabic and black seed or black cumin ...
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