24-07-2012 | Feng-Chun Yang, Karl Staser, D. Wade Clapp, Cancer Microenvironment, 2012

Dynamic interactions between tumorigenic cells and surrounding cells, including immunomodulatory hematopoietic cells, can dictate tumor initiation, progression, and transformation. Hematopoietic-stromal interactions underpin the plexiform neurofibroma, a debilitating tumor arising in ...

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10-07-2012 | David Tarin, Cancer Microenvironment, 2012

In normal tissues and organs, the activities of the constituent cells are strictly restricted to the tasks assigned to them during development. In addition they (with the exception of leukocytes) remain inflexibly confined to their territorial domains by regulatory interactions with their ...

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14-06-2012 | Yan Wu, Limin Zheng, Cancer Microenvironment, 2012

Human tumor tissues can often be anatomically classified into areas of cancer nest, invading edge, and peritumoral stroma, each with distinct compositions and functional properties. Macrophages (Mφ) constitute a major component of the leukocyte infiltrate in tumors. These cells are derived ...

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08-06-2012 | Lun-Xiu Qin, Cancer Microenvironment, 2012

Metastasis is a multistage process that requires cancer cells to escape from the primary tumor, survive in the circulation, seed at distant sites and grow. Each of these processes involves rate-limiting steps that are influenced by non-malignant cells of the tumor microenvironment. There are ...

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25-05-2012 | Jie Li, Lin Chen, Zhihai Qin, Cancer Microenvironment, 2012

Tumors are highly complex tissues composed of neoplastic cells and different kinds of stromal cells. Tumor stromal cells, especially fibroblasts, play important roles during the multistep development of tumors. In this review, the two-faced characteristics of tumor stromal fibroblasts are ...

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17-05-2012 | Bingxue Shang, Gaochuan Zhang, Yanyan Pan, Quansheng Zhou, Cancer Microenvironment, 2012

Tumor microenvironment (TME) is important in tumor development and may be a target for anti-cancer therapy. The genesis of TME is a dynamic process that is regulated by intrinsic and extrinsic factors and coordinated by multiple genes, cells, and signal pathways. Cancer anaerobic metabolism ...

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15-05-2012 | Ruowen Ge, Evan Tan, Soheila Sharghi-Namini, Harry H. Asada, Cancer Microenvironment, 2012

Cancer is a complex organ whose behavior is not only influenced by genetic and epigenetic changes in cancer cells but also by stromal cells, local extracellular matrix and specific tissue architecture. Intercellular communications within the cancer microenvironment are critical to coordinate ...

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06-05-2012 | Zhen-Yu Ding, Xue-Lin Zou, Yu-Quan Wei, Cancer Microenvironment, 2012

The cancer microenvironment is constituted of non-transformed host stromal cells such as endothelial cells, fibroblasts, various immune cells, and a complex extra-cellular matrix secreted by both the normal and neoplastic cells embedded in it. The importance of the microenvironment and its ...

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23-04-2012 | Izhak Haviv, Erik W. Thompson, Cancer Microenvironment, 2012

Soiling the Seed: Microenvironment and Epithelial Mesenchymal Plasticity Content Type Journal Article Category Preface Pages 1-3 DOI 10.1007/s12307-012-0104-0 Authors Izhak Haviv, Faculty of Medicine, Bar-Ilan University, Zfat, Israel Erik W. Thompson, St. Vincent’s Institute ...

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23-04-2012 | Yanping Ding, Nan Song, Yongzhang Luo, Cancer Microenvironment, 2012

Tumor growth relies on the formation of new blood vessels to receive an adequate supply of oxygen and nutrient. This process is facilitated by both the remodeling of the pre-existing vasculatures and the recruitment of the progenitor/stem cells originated from bone marrow-derived cells ...

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