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765 Newest Publications in british journal of clinical pharmacology
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Pharmacokinetics and Pharmacodynamics of Ponesimod, a Selective S1P1 Receptor Modulator, in the First‐in‐Human Study.
18-04-2013 | P Brossard, H Derendorf, J Xu, H Maatouk, A Halabi, J Dingemanse, British Journal of Clinical Pharmacology, 2013
Structure summary Aims This study investigated the tolerability, safety, pharmacokinetics, and pharmacodynamics of ponesimod, a novel oral selective sphingosine‐1‐phosphate (S1P1) receptor modulator in development for the treatment of auto‐immune diseases. Methods This was a ...
Trials and tribulations of skin iontophoresis in therapeutics
17-04-2013 | Matthieu Roustit, Sophie Blaise, Jean‐Luc Cracowski, British Journal of Clinical Pharmacology, 2013
Abstract Iontophoresis is a method of non‐invasive transdermal drug delivery based on the transfer of charged molecules using a low‐intensity electric current. Both local and systemic administration is possible, however the skin pharmacokinetics of iontophoretically‐delivered drugs is ...
UNDERSTANDING THE DOSE‐RESPONSE RELATIONSHIP OF ALLOPURINOL: PREDICTING THE OPTIMAL DOSAGE
16-04-2013 | Garry G Graham, Diluk R W Kannangara, Sophie L Stocker, Ian Portek, Kevin D Pile, Praveen L Indraratna, Indira Datta ..., British Journal of Clinical Pharmacology, 2013
Structured Summary Aims The aim of the study was to identify and quantify factors that control the plasma concentrations of urate during allopurinol treatment and to predict optimal doses of allopurinol. Methods Plasma concentrations of urate and creatinine (112 samples, 46 ...
An exploratory microdialysis study investigating the effect of repeated application of a diclofenac epolamine medicated plaster on prostaglandin concentrations in skeletal muscle after standardized physical exercise
01-04-2013 | A. Burian, V. Frangione, S. Rovati, G. Mautone, C. Leuratti, A. Vaccani, R. Crevenna, M. Keilani, B. Burian, M. Brun ..., British Journal of Clinical Pharmacology, 2013
Abstract Purpose Muscle injuries and extensive exercise are associated with cyclooxygenase dependent formation of inflammatory prostaglandins. Since the effect of topical administration of non‐steroidal anti‐inflammatory drugs (NSAIDs) on local cyclooxygenase is unknown, the present ...
Emerging role of long acting muscarinic antagonists for asthma
28-03-2013 | B J Lipworth, British Journal of Clinical Pharmacology, 2013
Summary Acetlycholine is involved in the control of airway smooth muscle constriction and in recruitment of inflammatory cells via neuronal and paracrine effects on muscarinic type 3 receptors. Long acting muscarinic antagonists (LAMA) are well established in guidelines for COPD but are ...
Tacrolimus Placental Transfer at Delivery and Neonatal Exposure through Breast Milk
26-03-2013 | Songmao Zheng, Thomas R. Easterling, Karen Hays, Jason G. Umans, Menachem Miodovnik, Shannon Clark, Justina C. Calam ..., British Journal of Clinical Pharmacology, 2013
Summary Aim(s) The current investigation aims to provide new insights into fetal exposure to tacrolimus in utero by evaluating maternal and umbilical cord blood (venous and arterial), plasma and unbound concentrations at delivery. This study also presents a case report of tacrolimus ...
A Time‐to‐Event Model for Acute Rejections in Paediatric Renal Transplant Recipients Treated with Ciclosporin A
25-03-2013 | Anne‐Kristina Frobel, Mats O Karlsson, Janne T Backman, Kalle Hoppu, Erik Qvist, Paula Seikku, Hannu Jalanko, Christ ..., British Journal of Clinical Pharmacology, 2013
abstract Aim Ciclosporin A (CsA) dosing in immunosuppression after paediatric kidney transplantation remains challenging, and appropriate target CsA exposures (AUC) are controversial. This study aimed to develop a time‐to‐first‐acute rejection (AR) model and to explore predictive ...
A Novel Approach to Pharmaco‐EEG for Investigating Analgesics: Assessment of Spectral Indices in Single‐Sweep Evoked Brain Potentials
25-03-2013 | Mikkel Gram, Carina Graversen, Anders K. Nielsen, Thomas Arendt‐Nielsen, Carsten D. Mørch, Trine Andresen, Asbjørn M ..., British Journal of Clinical Pharmacology, 2013
Summary Aims To compare results from analysis of averaged and single‐sweep EPs by visual inspection and spectral analysis in order to identify an objective measure for the analgesic effect of buprenorphine and fentanyl. Methods Twenty‐two healthy males were included in a ...
Clinical Pharmacology KNowledge, Opportunities and Working Strengths (CPKNOWS): A Competency Model for Pursuit of Excellence in Clinical Pharmacology
22-03-2013 | K A Nieforth, H Y Abdallah, P Smith, M Derks, B Boutouyrie, N Sarapa, R W Peck, British Journal of Clinical Pharmacology, 2013
A competency model for planning and monitoring Clinical Pharmacology staff development is presented. The method provides a means to objectively define, and monitor development of key skills and knowledge areas required to fulfill the role of Clinical Pharmacologist as practiced at Roche. ...
Vaccines against stimulants: Cocaine and Methamphetamine
20-03-2013 | Thomas Kosten, Coreen Domingo, Frank Orson, Berma Kinsey, British Journal of Clinical Pharmacology, 2013
Abstract Aims While the worldwide prevalence of cocaine use remains significant, medications, or small molecule approaches, to treat drug addictions have met with limited success. Anti‐addiction vaccines, on the other hand, have demonstrated great potential for treating drug abuse using ...
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