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782 Newest Publications in british journal of clinical pharmacology
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Potentially inappropriate prescribing and adverse health outcomes in community dwelling older patients
27-05-2013 | Caitriona Cahir, Kathleen Bennett, Conor Teljeur, Tom Fahey, British Journal of Clinical Pharmacology, 2013
Abstract Aims This study aimed to determine the association between potentially inappropriate prescribing (PIP) and health related outcomes (adverse drug events (ADEs), health related quality of life (HRQOL) and hospital accident and emergency (A&E) visits) in older community dwelling ...
Implications of Genome‐Wide Association Studies in Cancer Therapeutics
23-05-2013 | Jai N. Patel, Howard L. McLeod, Federico Innocenti, British Journal of Clinical Pharmacology, 2013
Summary Genome wide association studies (GWAS) provide an agnostic approach to identifying potential genetic variants associated with disease susceptibility, prognosis of survival, and/or predictive of drug response. Although these techniques are costly and interpretation of study results ...
Severity of the TGN1412 trial disaster cytokine storm correlated with IL‐2 release
23-05-2013 | David Eastwood, Chris Bird, Paula Dilger, Jason Hockley, Lucy Findlay, Stephen Poole, Susan J Thorpe, Meenu Wadhwa, ..., British Journal of Clinical Pharmacology, 2013
AIM To determine if cytokine release with a solid‐phase assay is predictive of adverse responses for a range of therapeutic mAbs. METHODS Cytokine ELISAs and a multi‐array system were used to compare responses generated by different therapeutic mAbs using a solid‐phase assay. Flow ...
Novel antibodies targeting immune regulatory checkpoints for cancer therapy
23-05-2013 | Chern Siang Lee, Mark Cragg, Martin Glennie, Peter Johnson, British Journal of Clinical Pharmacology, 2013
Abstract Cancers must evade or suppress the immune system in order to develop. Better understanding of the molecular regulation governing tumour detection and effective activation of the immune system (so‐called immune regulatory checkpoints) has provided new targets for cancer ...
The effect of Echinacea purpurea on the pharmacokinetics of docetaxel
23-05-2013 | A K L Goey, I Meijerman, H Rosing, J A Burgers, M Mergui‐Roelvink, M Keessen, S Marchetti, J H Beijnen, J H M Schellens, British Journal of Clinical Pharmacology, 2013
Summary AIMS The herbal medicine Echinacea purpurea has been shown to induce CYP3A4 both in vitro and in humans. This study explored whether Echinacea purpurea affects the pharmacokinetics of the CYP3A4 substrate docetaxel in cancer patients. METHODS Ten evaluable cancer patients ...
Prolonged ketamine infusion as a therapy for Complex Regional Pain Syndrome: Synergism with antagonism?
23-05-2013 | Anthony E. Pickering, Candida S. McCabe, British Journal of Clinical Pharmacology, 2013
Abstract Complex regional pain syndrome (CRPS) remains a troubling and often refractory pain condition for which the existing treatments are inadequate. The review by Niesters et al in this journal highlights the interesting findings of several recent studies of the NMDA receptor ...
Harms from medicines: inevitable, in error, or intentional
20-05-2013 | R E Ferner, British Journal of Clinical Pharmacology, 2013
Rational therapeutics requires a balance between benefits and harms. 1. Harm may be inevitable: some adverse drug reactions cannot be predicted or prevented. 2. Some harm occurs in error when a medicine is wrongly formulated, prescribed, dispensed, or administered; adverse drug reactions ...
Junior doctors’ perceptions of their self‐efficacy in prescribing, their prescribing errors and the possible causes of errors
30-04-2013 | Cristín Ryan, Sarah Ross, Peter Davey, Eilidh M Duncan, Shona Fielding, Jill J Francis, Marie Johnston, Jean Ker, Am ..., British Journal of Clinical Pharmacology, 2013
Summary Aims Explore and compare junior doctors’ perceptions of their self‐efficacy in prescribing, their prescribing errors and the possible causes of those errors. Methods A cross‐sectional questionnaire study was distributed to foundation doctors throughout Scotland, based on ...
Not‐in‐trial simulation I: bridging cardiovascular risk from clinical trials to real life conditions
25-04-2013 | ASY Chain, JP Dieleman, C Noord, A Hofman, BHC Stricker, M Danhof, MCJM Sturkenboom, O Della Pasqua, British Journal of Clinical Pharmacology, 2013
Summary Aim he assessment of QTc interval prolongation relies on the evidence of drug effects in healthy subjects. This study demonstrates the relevance of pharmacokinetic‐pharmacodynamic (PKPD) relationships to characterise drug‐induced QTc‐interval prolongation and explore the ...
Overview of Methods for Comparing the Efficacies of Drugs in the Absence of Head‐to ‐Head Clinical Trial Data
25-04-2013 | Hansoo Kim, Lyle Gurrin, Zanfina Ademi, Danny Liew, British Journal of Clinical Pharmacology, 2013
Abstract/Summary In most therapeutic areas, multiple drug options are increasingly becoming available, but there is often a lack of evidence from head‐to‐head clinical trials that allow for direct comparison of the efficacy and/or safety one drug versus another. This review provides an ...
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