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651 Newest Publications in biotechnology progress
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A possible mechanism of metabolic regulation in Gibberella fujikuroi using a mixed carbon source of glucose and corn oil inferred from analysis of the kinetics data obtained in a stirrer tank bioreactor
12-06-2013 | Erika Y. Rios‐Iribe, Oscar M. Hernández‐Calderón, C. Reyes‐Moreno, I. Contreras‐Andrade, Luis B. Flores‐Cotera, Elea ..., Biotechnology Progress, 2013
Abstract A non‐structured model was used to study the dynamics of gibberellic acid production in a stirred tank bioreactor. Experimental data were obtained from submerged batch cultures of Gibberella fujikuroi (CDBB H‐984) grown in varying ratios of glucose‐corn oil as the carbon source. ...
Effect of Selected Aldehydes Found in the Corncob Hemicellulose Hydrolysate on the Growth and Xylitol Fermentation of Candida tropicalis
12-06-2013 | Le Wang, Pingwah Tang, Xiaoguang Fan, Qipeng Yuan, Biotechnology Progress, 2013
Abstract The effects of four aldehydes (furfural, 5–hydroxymethylfurfural, vanillin and syringaldehyde), which were found in the corncob hemicellulose hydrolysate, on the growth and xylitol fermentation of Candida tropicalis were investigated. The results showed that vanillin was the most ...
Modeling of transient flow through a viscoelastic preparative chromatography packing
11-06-2013 | Dariusch Hekmat, Michael Kuhn, Verena Meinhardt, Dirk Weuster‐Botz, Biotechnology Progress, 2013
Abstract The common method for purification of macromolecular bioproducts is preparative packed‐bed chromatography using polymer‐based, compressible, viscoelastic resins. Due to a downstream processing bottleneck, the chromatography equipment is often operated at its hydrodynamic limit. ...
Effect of cell culture medium components on color of formulated monoclonal antibody drug substance
11-06-2013 | Natarajan Vijayasankaran, Sharat Varma, Yi Yang, Melissa Mun, Silvana Arevalo, Martin Gawlitzek, Trevor Swartz, Amy ..., Biotechnology Progress, 2013
Abstract As the industry moves towards subcutaneous delivery as a preferred route of drug administration, high drug substance concentrations are becoming the norm for monoclonal antibodies. At such high concentrations, the drug substance may display a more intense color than at the ...
Influence of pluronic® F68 on oxygen mass transfer
11-06-2013 | Christian Sieblist, Marco Jenzsch, Michael Pohlscheidt, Biotechnology Progress, 2013
Abstract Pluronic® F68 is one of the most used shear protecting additives in cell culture cultivations. It is well known from literature that such surface‐active surfactants lower the surface tension at the gas‐liquid interface, which influences the mass transfer. In this study, the ...
Separation and nanoencapsulation of antitumor polypeptide from Spirulina platensis
11-06-2013 | Bochao Zhang, Xuewu Zhang, Biotechnology Progress, 2013
Abstract Spirulina platensis is a multicellular edible blue‐green alga with abundant proteins (~60%). No report is available on the antitumor polypeptides from the whole proteins of S. platensis. In this study, for the first time, an antitumor polypeptide Y2 from trypsin digest of S. ...
New lipid‐producing, cold‐tolerant yellow‐green alga isolated from the rocky mountains of colorado
11-06-2013 | David R. Nelson, Sinafik Mengistu, Paul Ranum, Gail Celio, Mara Mashek, Douglas Mashek, Paul A. Lefebvre, Biotechnology Progress, 2013
A new strain of yellow‐green algae (Xanthophyceae, Heterokonta), tentatively named Heterococcus sp. DN1 (UTEX accession number UTEX ZZ885), was discovered among snow fields in the Rocky Mountains. Axenic cultures of H. sp. DN1 were isolated and their cellular morphology, growth, and ...
Model‐based identifiable parameter determination applied to a simultaneous saccharification and fermentation process model for bio‐ethanol production
08-06-2013 | Diana C. López C., Tilman Barz, Mariana Peñuela, Adriana Villegas, Silvia Ochoa, Günter Wozny, Biotechnology Progress, 2013
In this work, a methodology for the model‐based identifiable parameter determination (MBIPD) is presented. This systematic approach is proposed to be used for structure and parameter identification of nonlinear models of biological reaction networks. Usually, this kind of problems are ...
SO2‐catalyzed steam explosion: The effects of different severity on digestibility, accessibility, and crystallinity of lignocellulosic biomass
08-06-2013 | Yuzhi Kang, Prabuddha Bansal, Matthew J. Realff, Andreas S. Bommarius, Biotechnology Progress, 2013
Lignocellulosic biomass is the most promising feedstock for biofuels production. To enhance the efficiency of enzymatic hydrolysis, lignocellulosics needs to be pretreated to lower their recalcitrance. SO2‐catalyzed steam explosion is an efficient and relatively cost‐efficient pretreatment ...
Application of a nonradioactive method of measuring protein synthesis in industrially relevant chinese hamster ovary cells
08-06-2013 | Nazanin Dadehbeigi, Alan James Dickson, Biotechnology Progress, 2013
Due to the high medical and commercial value of recombinant proteins for clinical and diagnostic purposes, the protein synthesis machinery of mammalian host cells is the subject of extensive research by the biopharmaceutical industry. RNA translation and protein synthesis are steps that may ...
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