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395 Newest Publications in basic & clinical pharmacology & toxicology
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Evaluation of the Potency of Two Novel Bispyridinium Oximes (K456, K458) in Comparison with Oxime K203 and Trimedoxime to Counteract Tabun‐induced Neurotoxicity in Rats
06-05-2013 | Jiri Kassa, Jan Misik, Jana Zdarova Karasova, Basic & Clinical Pharmacology & Toxicology, 2013
Abstract The ability of two newly developed bispyridinium oximes (K456, K458) to reduce tabun‐induced acute neurotoxic signs and symptoms was compared with oxime K203 and trimedoxime using the Functional observational battery. The neuroprotective effects of the oximes studied combined ...
Intravenous Lipid Emulsion Entraps Amitriptyline into Plasma and Can Lower its Brain Concentration – an Experimental Intoxication Study in Pigs
03-05-2013 | Juho A. Heinonen, Erik Litonius, Janne T. Backman, Pertti J. Neuvonen, Per H. Rosenberg, Basic & Clinical Pharmacology & Toxicology, 2013
Abstract Intravenous lipid emulsion has been suggested as treatment for severe intoxications caused by lipophilic drugs, including tricyclic antidepressants. We investigated the effect of lipid infusion on plasma and tissue concentrations of amitriptyline and haemodynamic recovery, when ...
Lenalidomide at Therapeutic and Supra‐therapeutic Doses Does Not Prolong QTc Intervals in the Thorough QTc Study Conducted in Healthy Men
03-05-2013 | Nianhang Chen, Ying Ye, Liangang Liu, Josephine Reyes, Mahmoud S. Assaf, Claudia Kasserra, Simon Zhou, Maria Palmisano, Basic & Clinical Pharmacology & Toxicology, 2013
Abstract The effect of lenalidomide on the corrected QT (QTc) interval was evaluated in healthy men and extended to patients based on the lenalidomide concentration–QTc (C–QTc) relationship. A rigorous assessment of the effect of lenalidomide on QTc intervals was conducted in healthy ...
Statins and Cancer‐Related Mortality: An Open Question
30-04-2013 | Patrizia Gazzerro, Elena Ciaglia, Maurizio Bifulco, Basic & Clinical Pharmacology & Toxicology, 2013
HMG‐CoA reductase inhibitors, statins and pleiotropic effects have been associated with both increased and decreased cancer risk. This letter intends to contribute to ascertaining the real role of statins in cancer since there are conflicting results in the literature1. In the last volume ...
Melatonin Attenuates Isoflurane‐Induced Acute Memory Impairments in Aged Rats
29-04-2013 | Yajie Liu, Cheng Ni, Yi Tang, Xiaosheng Tian, Yang Zhou, Min Qian, Zhengqian Li, Dehua Chui, Xiangyang Guo, Basic & Clinical Pharmacology & Toxicology, 2013
Abstract Melatonin is an endogenous hormone with neuroprotective effects. Melatonin levels in elderly patients are reduced following surgeries that require anaesthesia. Whether reduced melatonin levels are important for postoperative cognitive dysfunction (POCD) remains unclear. Here, we ...
Cardioprotective Effects of Nicorandil, a Mitochondrial Potassium Channel Opener against Doxorubicin‐induced Cardiotoxicity in Rats
29-04-2013 | Ihab T. Abdel‐Raheem, Ashraf Taye, Mekky M. Abouzied, Basic & Clinical Pharmacology & Toxicology, 2013
Abstract Doxorubicin is a chemotherapeutic drug used to treat solid and haematopoietic tumours. Its use is limited by a major side effect of cardiotoxicity. It was reported that doxorubicin‐induced cardiotoxicity is mediated through oxidative stress coupled with impaired NO ...
Nephrectomised and Hepatectomised Animal Models as Tools in Preclinical Pharmacokinetics
15-04-2013 | Bill Vestergaard, Henrik Agersø, Jens Lykkesfeldt, Basic & Clinical Pharmacology & Toxicology, 2013
Abstract Early understanding the pharmacokinetics and metabolic patterns of new drug candidates is essential for selection of optimal candidates to move further in the drug development process. In vitro methodologies can be used to investigate metabolic patterns but in general, they lack ...
Curcumin Attenuates Diet‐Induced Hepatic Steatosis by Activating AMPK
09-04-2013 | Min Young Um, Kwang Hyun Hwang, Jiyun Ahn, Tae Youl Ha, Basic & Clinical Pharmacology & Toxicology, 2013
Abstract Curcumin is a well‐known component of traditional turmeric (Curcuma longa), which has been reported to prevent obesity and diabetes. However, the effect of curcumin on hepatic lipid metabolism remains unclear. The aim of this study was to examine the effects of curcumin on ...
Channeling of Statin Use towards Low‐Risk Population and Patients with Diabetes
09-04-2013 | Maria Rikala, Risto Huupponen, Arja Helin‐Salmivaara, Maarit Jaana Korhonen, Basic & Clinical Pharmacology & Toxicology, 2013
Abstract This study based on nationwide comprehensive health registers analysed trends in characteristics of statin users in the whole community‐dwelling population of Finland between 1999 and 2008. The annual number of incident users (defined as those purchasing statins for the first ...
L‐Amino Acid Oxidase Isolated from Bothrops pirajai Induces Apoptosis in BCR‐ABL Positive Cells and Potentiates Imatinib Mesylate Effect
03-04-2013 | Sandra Mara Burin, Lorena Rocha Ayres, Renata Peres Neves, Luciana Ambrósio, Fabiana Rossetto Morais, Marcelo Dias‐B ..., Basic & Clinical Pharmacology & Toxicology, 2013
Abstract Chronic myeloid leukaemia (CML) is a myeloproliferative disorder characterized by the presence of Philadelphia chromosome and by BCR‐ABL1, which encodes the BCR‐ABL oncoprotein. Although imatinib mesylate (IM) is effective for CML treatment, patients in accelerated and blastic ...
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