09-11-2012 | Olesya I. Zhuravleva, Shamil Sh. Afiyatullov, Olesya S. Vishchuk, Vladimir A. Denisenko, Natalya N. Slinkina, Olga F ..., Archives of Pharmacal Research, 2012

A new decaline derivative, decumbenone C (1) along with four known compounds, decumbenones A (2) and B (3), diorcinol (4), and brevianamide F (5) were isolated from the marine fungus Aspergillus sulphureus KMM 4640. Decumbenone C shows potent cytotoxic activity against SK-MEL-5 human melanoma ...

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09-11-2012 | Ning Zhang, Huadong Cui, Lili Yang, Archives of Pharmacal Research, 2012

Background Few studies have examined the effect of the angiotensin II type I receptor (AT1R) A1166C polymorphism on the antihypertensive effect of the angiotensin-converting-enzyme inhibitor benazepril in patients with hypertension, and no such studies have performed analysis using the ...

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09-11-2012 | Hye Jin Yang, Jin Yeul Ma, Jin Bae Weon, Bohyoung Lee, Choong Je Ma, Archives of Pharmacal Research, 2012

Soshiho-tang, one of the herbal prescriptions, has been used in treatment of chronic liver disease. In this study, the efficient high-performance liquid chromatography coupled with diode array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI-MS) method was ...

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09-11-2012 | Manh Heun Kim, Kwan Hee Park, Myeong Hwan Oh, Han Hyuk Kim, Kang In Choe, Sang Hee Park, Min Won Lee, Archives of Pharmacal Research, 2012

Chromatographic separation of the 80% MeOH extract of the leaves of Ilex rotunda (IR) led to isolation of two new hemiterpene glycosides, tentatively named as rotundarpenoside A (1) and rotundarpenoside B (2), along with five known caffeoyl derivatives (3–7). The chemical structures of these ...

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09-11-2012 | Hak Jae Kim, Tae Hwan Kim, Won Sik Seo, Sun Dong Yoo, Il Han Kim, Sang Hoon Joo, Soyoung Shin, Eun-Seok Park, Eun So ..., Archives of Pharmacal Research, 2012

This study reports the pharmacokinetics and tissue distribution of a novel histone deacetylase and DNA methyltransferase inhibitor, psammaplin A (PsA), in mice. PsA concentrations were determined by a validated LC-MS/MS assay method (LLOQ 2 ng/mL). Following intravenous injection at a dose of ...

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09-11-2012 | Usama W. Hawas, Ahmed Atef El-Beih, Ali M. El-Halawany, Archives of Pharmacal Research, 2012

The marine fungus Aspergillus versicolor was isolated from the inner tissue of the Red Sea green alga Halimeda opuntia. The fungus was identified by its morphology and 18s rDNA. Cultivation of this fungal strain led to a new metabolite named isorhodoptilometrin-1-methyl ether (1) along with ...

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09-11-2012 | Tae Joung Ha, Myoung-Hee Lee, Hyun-Tae Kim, Hyun Sook Kwon, In-Youl Baek, Isao Kubo, Dae Sik Jang, Archives of Pharmacal Research, 2012

Luteolin, isolated from the seeds of Perilla frutescens (perilla seeds), inhibited the peroxidation of linoleic acid catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, Type 1) with an IC50 of 5.0 M (1.43 μg/mL) noncompetitively. The progress curves for an enzyme reaction indicate that ...

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09-11-2012 | Hee Jin Jung, Hyun Ah Jung, Sam Sik Kang, Je-Hyun Lee, Yoon Sook Cho, Kyong Ho Moon, Jae Sue Choi, Archives of Pharmacal Research, 2012

As part of our continuous search for compounds from natural sources that can treat diabetes and its diabetic complications, in the present work, we investigated the protein tyrosine phosphatase 1B (PTP1B) and rat lens aldose reductase (RLAR) inhibitory activities of the roots of Aralia ...

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09-11-2012 | Seung Woong Lee, Byung Soon Hwang, Mi-Hwa Kim, Chan-Sun Park, Woo Song Lee, Hyun-Mee Oh, Mun-Chual Rho, Archives of Pharmacal Research, 2012

Six stilbenes were isolated from the methanol extract of Rheum undulatum rhizomes by bioactivity-guided fractionation. The structures of the compounds were determined by spectroscopic analysis (1H-, 13C-NMR and MS), to be desoxyrhapontigenin (1), rhapontigenin (2), trans-resveratrol (3), ...

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09-11-2012 | Yong Zhu, Xin Chen, Zeng Wu, Yixuan Zheng, Yadong Chen, Weifang Tang, Tao Lu, Archives of Pharmacal Research, 2012

A series of diaryl ether hydroxamic acids were synthesized for the first time and evaluated for the HDAC biology and antiproliferative activity. The structures of these new hydroxamic acids derivatives were confirmed by IR, 1H-NMR and mass spectrum. Some of these compounds showed micro molar ...

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