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393 Newest Publications in addiction biology
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μ‐Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche
06-03-2013 | Candice Contet, Airee Kim, David Le, Siddharth K. Iyengar, Roxanne W. Kotzebue, Clara J. Yuan, Brigitte L. Kieffer, ..., Addiction Biology, 2013
Abstract Ethanol exposure and withdrawal alter the generation of new neurons in the adult hippocampus. The endogenous opioid system, particularly the μ‐opioid receptor (MOR), can modulate neural progenitors and also plays a critical role in ethanol drinking and dependence. In the present ...
MeCP2 regulates ethanol sensitivity and intake
01-03-2013 | Vez Repunte‐Canonigo, Jihuan Chen, Celine Lefebvre, Tomoya Kawamura, Max Kreifeldt, Oan Basson, Amanda J. Roberts, P ..., Addiction Biology, 2013
Abstract We have investigated the expression of chromatin‐regulating genes in the prefrontal cortex and in the shell subdivision of the nucleus accumbens during protracted withdrawal in mice with increased ethanol drinking after chronic intermittent ethanol (CIE) vapor exposure and in ...
Involving the cerebellum in cocaine‐induced memory: pattern of cFos expression in mice trained to acquire conditioned preference for cocaine
28-02-2013 | María Carbo‐Gas, Dolores Vazquez‐Sanroman, Luisa Aguirre‐Manzo, Genaro A. Coria‐Avila, Jorge Manzo, Carla Sanchis‐Se ..., Addiction Biology, 2013
Abstract Because of its primary role in drug‐seeking, consumption and addictive behaviour, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug‐related memories. Human studies, which focused on ...
Abstinence duration modulates striatal functioning during monetary reward processing in cocaine patients
28-02-2013 | Juan‐Carlos Bustamante, Alfonso Barrós‐Loscertales, Víctor Costumero, Paola Fuentes‐Claramonte, Patricia Rosell‐Negr ..., Addiction Biology, 2013
Abstract Pre‐clinical and clinical studies in cocaine addiction highlight alterations in the striatal dopaminergic reward system that subserve maintenance of cocaine use. Using an instrumental conditioning paradigm with monetary reinforcement, we studied striatal functional alterations in ...
Brain‐derived neurotrophic factor mediates the suppression of alcohol self‐administration by memantine
17-02-2013 | Jérôme Jeanblanc, Fabien Coune, Béatrice Botia, Mickaël Naassila, Addiction Biology, 2013
Abstract Brain‐derived neurotrophic factor (BDNF) within the striatum is part of a homeostatic pathway regulating alcohol consumption. Memantine, a non‐competitive antagonist of N‐methyl‐D‐aspartate receptors, induces expression of BDNF in several brain regions including the striatum. We ...
Genome‐wide DNA methylation analysis in alcohol dependence
07-02-2013 | Ruiling Zhang, Qin Miao, Chuansheng Wang, Rongrong Zhao, Wenqiang Li, Colin N. Haile, Wei Hao, Xiang Yang Zhang, Addiction Biology, 2013
Abstract Genetic, epigenetic, and environmental factors influence the development of alcohol dependence (AD). Recent studies have shown that DNA methylation markers in peripheral blood may serve as risk markers for AD. Yet a genome‐wide epigenomic approach investigating the role of DNA ...
Withdrawal effect of chronic amphetamine exposure during adolescence on complex maze performance
04-02-2013 | Daniel M. Krall, Stephanie L. Lim, Abby M. Cooper, Paul W. Burleson, Derek J. Rhoades, Stephen J. Jacquemin, Daryl C ..., Addiction Biology, 2013
Abstract National survey data suggest a steady increase in the diagnosis and treatment of mental disorders in children, particularly Attention Deficit/Hyperactivity Disorder (ADHD). As nearly all children diagnosed with ADHD are prescribed stimulant drugs, rationale exists to ...
Mephedrone (4‐methylmethcathinone) supports intravenous self‐administration in Sprague‐Dawley and Wistar rats
31-01-2013 | Shawn M. Aarde, Deepshikha Angrish, Deborah J. Barlow, M. Jerry Wright Jr, Sophia A. Vandewater, Kevin M. Creehan, K ..., Addiction Biology, 2013
Abstract Recreational use of the drug 4‐methylmethcathinone (mephedrone; 4‐MMC) became increasingly popular in the United Kingdom in recent years, spurred in part by the fact that it was not criminalized until April 2010. Although several fatalities have been associated with consumption ...
Using genetic information from candidate gene and genome‐wide association studies in risk prediction for alcohol dependence
31-01-2013 | Jia Yan, Fazil Aliev, Bradley T. Webb, Kenneth S. Kendler, Vernell S. Williamson, Howard J. Edenberg, Arpana Agrawal ..., Addiction Biology, 2013
Abstract Family‐based and genome‐wide association studies (GWAS) of alcohol dependence (AD) have reported numerous associated variants. The clinical validity of these variants for predicting AD compared with family history information has not been reported. Using the Collaborative Study ...
Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF‐R1 antagonist, CP‐376395
31-01-2013 | Jeffrey A. Simms, Carsten K. Nielsen, Rui Li, Selena E. Bartlett, Addiction Biology, 2013
Abstract Corticotrophin‐releasing factor (CRF) is a mediator of stress responses and a key modulator of ethanol‐mediated behaviors. We report here that the CRF receptor 1 (CRF‐R1) antagonist, CP‐376395 reduces 20% ethanol consumption in animals trained to consume ethanol on an ...
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