18-05-2013 | Ashwin Agarwal, Lauren C. Sayres, Mildred K. Cho, Robert Cook‐Deegan, Subhashini Chandrasekharan, Prenatal Diagnosis, 2013

ABSTRACT Cell‐free fetal DNA‐based noninvasive prenatal testing (NIPT) could significantly change the paradigm of prenatal testing and screening. Intellectual property (IP) and commercialization promise to be important components of the emerging debate about clinical implementation of ...

more

18-05-2013 | Judith M. E. Walsh, James D. Goldberg, Prenatal Diagnosis, 2013

ABSTRACT The American College of Obstetricians and Gynecologists currently recommends that all pregnant women be offered screening for chromosomal abnormalities, regardless of maternal age. Traditional screening tests have detection rates ranging from 85% to 90% and false‐positive rates ...

more

17-05-2013 | M. A. J. Engels, J. W. R. Twisk, M. A. Blankenstein, J. M. G. Vugt, Prenatal Diagnosis, 2013

ABSTRACT Objective To compare screening performance for Down syndrome (DS) of the absolute risk (AR) method to the first‐trimester combined test (FCT) at different maternal ages. Methods Retrospective analysis of 32,448 FCT. AR was defined as final risk divided by maternal age ...

more

15-05-2013 | Mika Ohno, Aaron B. Caughey, Prenatal Diagnosis, 2013

ABSTRACT Objective As the sensitivity and specificity of noninvasive prenatal testing (NIPT) that uses cell‐free fetal DNA in maternal serum to identify Down syndrome in utero improves, NIPT could be considered a diagnostic test thus avoiding the complications of chorionic villus ...

more

15-05-2013 | Howard Cuckle, Peter Benn, Eugene Pergament, Prenatal Diagnosis, 2013

ABSTRACT Objective To determine the principal factors contributing to the cost of avoiding a birth with Down syndrome, using cell free (cf)DNA to replace conventional screening. Methods A range of unit costs were assigned to each item in the screening process. Detection rates ...

more

09-05-2013 | Janice Lim, Wendy L. Whittle, Yee‐Man Lee, Greg Ryan, Tim Van Mieghem, Prenatal Diagnosis, 2013

ABSTRACT Objective This study was designed to assess the accuracy of ultrasound anatomy screening before 17 weeks gestation in a population at high risk of fetal anomalies. Methods Retrospective review of anatomy ultrasound examinations done between 12‐17 weeks gestation in a ...

more

08-05-2013 | Li Zhen, Xin Yang, Yuen Ha Ting, Min Chen, Tak Yeung Leung, Prenatal Diagnosis, 2013

ABSTRACT Objective To investigate the agreement between manual and semi‐automated system and the effect of different image settings on intracranial translucency (IT) measurement. Methods A prospective study was conducted on 55 women carrying singleton pregnancy who attended first ...

more

08-05-2013 | Mariarosaria Di Tommaso, Viola Seravalli, Francesca Salvianti, Cecilia Bussani, Lucia Pasquini, Adalgisa Cordisco, P ..., Prenatal Diagnosis, 2013

ABSTRACT Objective To estimate whether chorionic villous sampling (CVS) causes a significant increase of cell‐free fetal DNA (cffDNA) in maternal circulation. Method Fifty pregnant women with singleton pregnancy were recruited prior to CVS. Maternal peripheral blood was collected ...

more

08-05-2013 | Irene T. M. Lindenburg, Jeanine M. Klink, Vivianne E. H. J. Smits‐Wintjens, Inge L Kamp, Dick Oepkes, Enrico Lopriore, Prenatal Diagnosis, 2013

ABSTRACT Perinatal survival rates after intrauterine transfusions (IUT) for red cell alloimmunisation now exceed 90%, which demonstrates the safety and efficacy of one of the most successful procedures in fetal therapy. However, improved perinatal survival could lead to an increased ...

more

06-05-2013 | Graham Tydeman, Isobel Clegg, Sharon Brown, Prenatal Diagnosis, 2013

What's already known about this topic? Detection rates of some of the prenatal conditions have been established only from long term regional or national studies No previous published work has evaluated whether the FASP recommendation that individual units should annually audit their ...

more