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1,138 Newest Publications from the industry biotechnology
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Stress‐induced lncRNAs evade nuclear degradation and enter the translational machinery
12-03-2013 | Josephine Galipon, Atsuko Miki, Arisa Oda, Toshifumi Inada, Kunihiro Ohta, Genes to Cells, 2013
Long noncoding RNAs (lncRNAs) play important roles in the regulation of gene expression. In fission yeast, glucose starvation triggers a transcriptional cascade of polyadenylated lncRNAs in the upstream region of the fructose‐1,6‐bisphosphatase gene (fbp1+), which is correlated with ...
UDP-Glucose Pyrophosphorylase Is a Novel Plant Cell Death Regulator
12-03-2013 | Stephen Chivasa; Daniel F. A. Tomé; Antoni R. Slabas, Journal of Proteome Research, 2013
Programmed cell death (PCD) is an essential process that functions in plant organ sculpture, tissue differentiation, nutrient recycling, and defense against pathogen attack. A full understanding of the mechanism of PCD in plants is hindered by the limited identification of protein components ...
Improved polyhydroxybutyrate production by Saccharomyces cerevisiae through the use of the phosphoketolase pathway
01-03-2013 | Kanokarn Kocharin, Verena Siewers, Jens Nielsen, Biotechnology and Bioengineering, 2013
Abstract The metabolic pathways of the central carbon metabolism in Saccharomyces cerevisiae are well studied and consequently S. cerevisiae has been widely evaluated as a cell factory for many industrial biological products. In this study, we investigated the effect of engineering the ...
A quantitative approach for understanding small‐scale human mesenchymal stem cell culture – implications for large‐scale bioprocess development
28-02-2013 | Qasim A. Rafiq, Karen Coopman , Alvin W. Nienow , Christopher J. Hewitt, Biotechnology Journal, 2013
Abstract Human mesenchymal stem cell (hMSC) therapies have the potential to revolutionise the healthcare industry and replicate the success of the therapeutic protein industry; however, for this to be achieved there is a need to apply key bioprocessing engineering principles and adopt a ...
Systems metabolic engineering of xylose utilizing Corynebacterium glutamicum for production of 1,5‐diaminopentane
28-02-2013 | Nele Buschke, Judith Becker, Rudolf Schäfer, Patrick Kiefer, Rebekka Biedendieck, Christoph Wittmann, Biotechnology Journal, 2013
Abstract The sustainable production of chemicals from renewable, non‐food raw materials is one of the great challenges in industrial biotechnology. Corynebacterium glutamicum was metabolically engineered for the production of the bio‐nylon precursor 1,5‐diaminopentane from the ...
Renewable bio ionic liquids‐water mixtures‐mediated selective removal of lignin from rice straw: Visualization of changes in composition and cell wall structure
22-02-2013 | Xue‐Dan Hou, Ning Li, Min‐Hua Zong, Biotechnology and Bioengineering, 2013
Abstract Pretreatment of rice straw by using renewable cholinium amino acids ionic liquids ([Ch][AA] ILs)‐water mixtures and the subsequent enzymatic hydrolysis of the residues were conducted in the present work. Of the eight mixtures composed of ILs and water, most were found to be ...
Quantitating intraparticle O2 gradients in solid supported enzyme immobilizates: Experimental determination of their role in limiting the catalytic effectiveness of immobilized glucose oxidase
21-02-2013 | Juan M. Bolivar, Tanja Consolati, Torsten Mayr, Bernd Nidetzky, Biotechnology and Bioengineering, 2013
Abstract Enzymatic O2‐dependent oxidations are receiving increased attention for use in fine chemicals synthesis. Solid supported oxidation catalysts often show poor efficiency due to pronounced O2 diffusion restriction. Internal O2 supply therefore constitutes a key parameter for ...
Metabolic engineering of Escherichia coli for the production of fumaric acid
21-02-2013 | Chan Woo Song, Dong In Kim, Sol Choi, Jae Won Jang, Sang Yup Lee, Biotechnology and Bioengineering, 2013
Abstract Fumaric acid is a naturally occurring organic acid which is an intermediate of the tricarboxylic acid cycle. Fungal species belonging to Rhizopus have traditionally been employed for the production of fumaric acid. In this study, Escherichia coli was metabolically engineered for ...
Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic β‐cell failure in type 2 diabetes
15-02-2013 | Dong Han, Yasuhiko Yamamoto, Seiichi Munesue, So Motoyoshi, Hidehito Saito, Myat Thu Thu Win, Takuo Watanabe, Koichi ..., Genes to Cells, 2013
Glucolipotoxicity, which is exerted by free fatty acids (FFA) and prolonged hyperglycemia, is implicated in pancreatic β‐cell failure in diabetes. Pattern recognition receptors such as receptor for advanced glycation end products (RAGE) and toll‐like receptors 2 and 4 could mediate danger ...
Embryonic Sex Induces Differential Expression of Proteins in Bovine Uterine Fluid
15-02-2013 | Enrique Gómez; José N. Caamaño; Fernando J. Corrales; Carmen Díez; Eva Correia-Álvarez; David Martín; Beatriz Trigal ..., Journal of Proteome Research, 2013
The bovine endometrium recognizes early embryos and reacts differently depending on the developmental potential of the embryo. However, it is unknown whether the endometrium can distinguish embryonic sex. Our objective was to analyze sexual dimorphism in the uterus in response to male and ...
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