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202,410 Newest Publications
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The epigenetic potentials of dietary polyphenols in prostate cancer management
23-10-2013 | Ata Abbas, William Patterson III, Philippe T. Georgel, Biochemistry and Cell Biology, 2013
Le cancer de la prostate est une maladie grandement affectée par le style de vie, particulièrement la diète, et il est plus fréquent aux États-Unis et dans les pays européens comparativement à l'Asie de sud et de l'est. Parmi les nombreuses causes et facteurs de risques connus, la nutrition ...
Otitis media in the Tgif knockout mouse implicates TGF{beta} signalling in chronic middle ear inflammatory disease
01-07-2013 | Hilda Tateossian; Susan Morse; Andrew Parker; Philomena Mburu; Nick Warr; Abraham Acevedo-Arozena; Michael Cheeseman ..., Human Molecular Genetics, 2013
Otitis media with effusion (OME) is the most common cause of hearing loss in children and tympanostomy to alleviate the condition remains the commonest surgical intervention in children in the developed world. Chronic and recurrent forms of OM are known to have a very significant genetic ...
Predicting the impact of diet and enzymopathies on human small intestinal epithelial cells
01-07-2013 | Swagatika Sahoo; Ines Thiele, Human Molecular Genetics, 2013
Small intestinal epithelial cells (sIECs) have a significant share in whole body metabolism as they perform enzymatic digestion and absorption of nutrients. Furthermore, the diet plays a key role in a number of complex diseases including obesity and diabetes. The impact of diet and altered ...
The secondary cell wall polysaccharide of Bacillus anthracis provides the specific binding ligand for the C-terminal cell wall-binding domain of two phage endolysins, PlyL and PlyG
01-07-2013 | Jhuma Ganguly; Lieh Y Low; Nazia Kamal; Elke Saile; L Scott Forsberg; Gerardo Gutierrez-Sanchez; Alex R Hoffmaster; ..., Glycobiology , 2013
Endolysins are bacteriophage enzymes that lyse their bacterial host for phage progeny release. They commonly contain an N-terminal catalytic domain that hydrolyzes bacterial peptidoglycan (PG) and a C-terminal cell wall-binding domain (CBD) that confers enzyme localization to the PG ...
Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error
01-07-2013 | Dwight Stambolian; Robert Wojciechowski; Konrad Oexle; Mario Pirastu; Xiaohui Li; Leslie J. Raffel; Mary Frances Cot ..., Human Molecular Genetics, 2013
Visual refractive errors (REs) are complex genetic traits with a largely unknown etiology. To date, genome-wide association studies (GWASs) of moderate size have identified several novel risk markers for RE, measured here as mean spherical equivalent (MSE). We performed a GWAS using a total ...
Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3
01-07-2013 | Ping K. Chan; Raul Torres; Cihangir Yandim; Pui P. Law; Sanjay Khadayate; Marta Mauri; Crina Grosan; Nadine Chapman- ..., Human Molecular Genetics, 2013
Large intronic expansions of the triplet-repeat sequence (GAA.TTC) cause transcriptional repression of the Frataxin gene (FXN) leading to Friedreich's ataxia (FRDA). We previously found that GAA-triplet expansions stimulate heterochromatinization in vivo in transgenic mice. We report here ...
PINK1 rendered temperature sensitive by disease-associated and engineered mutations
01-07-2013 | Derek P. Narendra; Chunxin Wang; Richard J. Youle; John E. Walker, Human Molecular Genetics, 2013
Mutations in Parkin or PINK1 are the most common cause of recessively inherited parkinsonism. Parkin and PINK1 function in a conserved mitochondrial quality control pathway, in which PINK1, a putative mitochondrial kinase, directs Parkin, a cytosolic E3 ubiquitin ligase, selectively to ...
Development and characterization of a specific IgG monoclonal antibody toward the Lewis x antigen using splenocytes of Schistosoma mansoni-infected mice
01-07-2013 | Msano Mandalasi; Nelum Dorabawila; David F Smith; Jamie Heimburg-Molinaro; Richard D Cummings; A Kwame Nyame, Glycobiology , 2013
The parasitic blood fluke Schistosoma mansoni synthesizes immunogenic glycans containing the human Lewis x antigen (Lex; Galactose-β1-4(Fucα1-3)N-acetylglucosamine-β-R, also called CD15), but the biological role(s) of this antigen in the parasites and in humans is poorly understood. To ...
Chemoenzymatic synthesis of glycosaminoglycans: Re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains
01-07-2013 | Paul L DeAngelis; Jian Liu; Robert J Linhardt, Glycobiology , 2013
Glycosaminoglycans (GAGs) are complex polysaccharides composed of hexosamine-containing disaccharide repeating units. The three most studied classes of GAGs, heparin/heparan sulfate, hyaluronan and chondroitin/dermatan sulfate, are essential macromolecules. GAGs isolated from animal and ...
Exclusive skeletal muscle correction does not modulate dystrophic heart disease in the aged mdx model of Duchenne cardiomyopathy
01-07-2013 | Nalinda B. Wasala; Brian Bostick; Yongping Yue; Dongsheng Duan, Human Molecular Genetics, 2013
Duchenne muscular dystrophy (DMD) is characterized by severe degeneration and necrosis of both skeletal and cardiac muscle. While many experimental therapies have shown great promise in treating skeletal muscle disease, an effective therapy for Duchenne cardiomyopathy remains a challenge in ...
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