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Kendall Houk, a recently elected member of the National Academy of Sciences and the Winstein Chair in Organic Chemistry at the University of California, Los Angeles, uses computational and theoretical chemistry to illuminate the underlying rules of organic and synthetic chemistry. By understanding how basic chemical reactions work, Houk can design molecules and enzymes to catalyze increasingly complex reactions. In his Inaugural Article, Houk uses molecular dynamics techniques to study the intricate underpinnings of the Diels-Alder reaction, a classic organic chemistry phenomenon first described in the 1920s. Here, he describes how theoretical and computational chemistry, bolstered by major advances in...

Authors:   Beth Azar
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   109
Issue:   32
Year:   2012
Pages:   12839
DOI:   10.1073/pnas.1210584109
Publication date:   07-08-2012

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