my.bionity.com
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
Inhibitors of dipeptidyl peptidase-4 (DPP-IV), a key regulator of the actions of incretin hormones, exert antihyperglycemic effects in type 2 diabetic patients. A major question concerns the potential ability of long term DPP-IV inhibition to have beneficial disease-modifying effects, specifically to attenuate loss of pancreatic β-cell mass due to oxidative stress induced inflammation. Here, we investigated the effects of a potent and selective DPP-4 inhibitor, an analog of vildagliptin (PKF-275-055), on glycemic control, pancreatic β-cell mass, genes and proteins expressions, tumor necrosis factor-alpha, and nitric oxide in an n2-STZ diabetic model of rat with defects in insulin sensitivity and secretion. To induce NIDDM, streptozotocin (STZ) 90mg/kg was administered i.p. to a group of 2days old pups. Diabetic rats were administered orally with vildagliptin analog PKF-275-055. Saline treated animals served as diabetic control. Significant and dose-dependent correction of postprandial hyperglycemia was observed in diabetic rats following 8weeks of chronic therapy. Treatment with PKF-275-055 showed increased the number of insulin-positive β-cells in islets and improved the expressions of genes and proteins are responsible for insulin secretions. In addition, treatment of rats with PKF-275-055 significantly increased insulin content, glycogen content and total proteins content; and decreased the inflammatory markers i.e. nitric oxide and TNF-alpha. The present studies indicate that PKF-275-055 is a novel selective DPP-IV inhibitor having potential to reduce inflammation that might be a potential agent for type 2 diabetes.
Graphical abstract
| Authors: | Atul Sureshrao Akarte, B.P. Srinivasan, Sonia Gandhi, Sushant Sole | |
| Journal: | European Journal of Pharmaceutical Science | |
| Year: | 2012 | |
| DOI: | 10.1016/j.ejps.2012.07.003 | |
| Publication date: | 06-08-2012 |
Watchlist
This is where you can add this publication to your personal favourites.
Additional Information
Production of advanced biofuels in engineered E. coli
Publication date: Available online 6 May 2013 Source:Current Opinion in Chemical Biology Author(s): Miao Wen , Brooks B Bond-Watts , Michelle CY Chang Commercial fermentation processes have long taken advantage of the synthetic power of living systems to rapidly and efficiently tra ... more
Protein conjugation with genetically encoded unnatural amino acids
Publication date: Available online 9 May 2013 Source:Current Opinion in Chemical Biology Author(s): Chan Hyuk Kim , Jun Y Axup , Peter G Schultz The site-specific incorporation of unnatural amino acids with orthogonal chemical reactivity into proteins enables the synthesis of struc ... more
Chemistry and combustion of fit-for-purpose biofuels
Publication date: Available online 8 May 2013 Source:Current Opinion in Chemical Biology Author(s): David A Rothamer , Timothy J Donohue From the inception of internal combustion engines, biologically derived fuels (biofuels) have played a role. Nicolaus Otto ran a predecessor to to ... more
Novel study reports marijuana users have better blood sugar control
Regular marijuana use is associated with favorable indices related to diabetic control, say investigators. They found that current marijuana users had significantly lower fasting insulin and were less likely to be insulin resistant, even after excluding patients with a diagnosis of diabetes ... more
More severe concussion symptoms lead to longer recovery time
Most children who suffer from sports-related concussions recover within a few days. However, in a small number of children, symptoms can last for a month or more. Although there have been numerous theories as to what might predict a longer recovery time, there is no definitive answer as to ... more
For breast cancer screening, one size doesn’t fit all
Although mammography, the gold standard of breast cancer screening, reduces breast cancer mortality, it has important limitations. Critics point to reduced sensitivity for women with dense breasts, a high rate of false positives leading to excessive biopsies, and concerns about long-term ef ... more
Über CHEMIE.DE
CHEMIE.DE Information Service GmbH runs specialist scientific internet portals. The secret to our success? We are familiar with what we publish.
Advertising at CHEMIE.DE
Our advertising formats support you in getting your message across to a clearly defined target audience.
© 1997-2013 CHEMIE.DE Information Service GmbH, All rights reserved
Netmeeting
