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T cells that escaped immune regulation and subsequently target insulin-producing β-cells are thought to be a major contributor of type 1 diabetes (T1D) development (1). Thus, harnessing autoreactive effector T cells appears to be a central requirement for novel therapeutic approaches that are urgently needed. The studies by Lee et al. (2) and Penaranda et al. (3) in PNAS demonstrate that blockade of IL-7 signaling can revert recent onset diabetes by fostering the inhibitory programmed cell death 1 (PD-1) protein on diabetogenic T cells, thereby limiting their autoaggressive potential.pnas;109/31/12270/FIG01F1fig01Fig. 1.IL-7 and PD-1 have antagonistic effects in the regulation of immune...
| Authors: | Tobias Boettler; Matthias von Herrath | |
| Journal: | Proceedings of the National Academy of Sciences current issue | |
| Volume: | 109 | |
| Issue: | 31 | |
| Year: | 2012 | |
| Pages: | 12270 | |
| DOI: | 10.1073/pnas.1209749109 | |
| Publication date: | 31-07-2012 |
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