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Abstract
Although there has been considerable research conducted regarding the long‐term affects of prenatal exposure to nicotine, there has been little examination of how this experience influences brain development. This study was designed to examine if there are morphological changes (dendritic branching, dendritic length, and spine density) in mPFC, OFC, parietal cortex, and nucleus accumbens associated with exposure to nicotine during gestation. Nicotine or saline was administered to pregnant Long Evans dams for the duration of pregnancy. Golgi‐cox techniques were used to examine neuroanatomy of offspring at postnatal day 21. The dendritic changes identified in rats exposed to nicotine prenatally resembled neuroanatomical changes that are identified in rats administered nicotine in adulthood. Of the 18 anatomical parameters measured, 11 exhibited significant modification, with two parameters, apical and basilar spine density in parietal cortex demonstrating sex‐dependent modification. These early changes in anatomy and behavior have important implications for later plasticity and long‐term wellbeing. © 2012 Wiley Periodicals, Inc.
| Authors: | A. Muhammad, R. Mychasiuk, A. Nakahashi, S. Hossain, R. Gibb, B. Kolb | |
| Journal: | Synapse | |
| Year: | 2012 | |
| Pages: | n/a | |
| DOI: | 10.1002/syn.21589 | |
| Publication date: | 27-07-2012 |
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