Early origins of heart disease: Low birth weight and the role of the insulin‐like growth factor system in cardiac hypertrophy

Abstarct

studies indicate that poor growth before birth is associated with left ventricular hypertrophy and an increased risk of death from heart disease later in life.
In fetal life, the insulin‐like growth factor (IGF) system has been implicated in physiological growth of the heart, while in postnatal life IGFs can be involved in both physiological and pathological cardiac hypertrophy.
A reduction in substrate supply in fetal life, resulting in chronic hypoxaemia and intrauterine growth restriction, results in increased cardiac IGF‐1R, IGF‐2 and IGF‐2R gene expression; and there is also evidence for a role of the IGF‐2R in the ensuing cardiac hypertrophy.
The persistent high level of cardiac IGF‐2R gene expression from fetal to postnatal life may be due to epigenetic changes in key cardiac hypertrophy regulatory pathways.

Authors:		Kimberley C.W. Wang, Kimberley J. Botting, Monalisa Padhee, Song Zhang, I. Caroline McMillen, Catherine M. Suter, Doug A. Brooks, Janna L. Morrison
Journal:		Clinical and Experimental Pharmacology and Physiology
Year:		2012
Pages:		n/a
DOI:		10.1111/j.1440-1681.2012.05743.x
Publication date:		07-07-2012

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insulin-like growth factor
cardiovascular disease
gene expression

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