my.bionity.com
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
by Matthias Kahm, Clara Navarrete, Vicent Llopis-Torregrosa, Rito Herrera, Lina Barreto, Lynne Yenush, Joaquin Ariño, Jose Ramos, Maik Kschischo
The intrinsic ability of cells to adapt to a wide range of environmental conditions is a fundamental process required for survival. Potassium is the most abundant cation in living cells and is required for essential cellular processes, including the regulation of cell volume, pH and protein synthesis. Yeast cells can grow from low micromolar to molar potassium concentrations and utilize sophisticated control mechanisms to keep the internal potassium concentration in a viable range. We developed a mathematical model for Saccharomyces cerevisiae to explore the complex interplay between biophysical forces and molecular regulation facilitating potassium homeostasis. By using a novel inference method (“the reverse tracking algorithm”) we predicted and then verified experimentally that the main regulators under conditions of potassium starvation are proton fluxes responding to changes of potassium concentrations. In contrast to the prevailing view, we show that regulation of the main potassium transport systems (Trk1,2 and Nha1) in the plasma membrane is not sufficient to achieve homeostasis.| Authors: | Matthias Kahm et al. | |
| Journal: | PLoS Computational Biology | |
| Volume: | 8 | |
| Issue: | 6 | |
| Year: | 2012 | |
| Pages: | e1002548 | |
| DOI: | 10.1371/journal.pcbi.1002548 | |
| Publication date: | 21-06-2012 |
Watchlist
This is where you can add this publication to your personal favourites.
Additional Information
by Jun Zhang, Jianhong Wang, Daoying Geng, Yuxin Li, Donglei Song, Yuxiang Gu Background/Aims The 256-slice CT enables the entire brain to be scanned in a single examination. We evaluated the application of 256-slice whole-brain CT perfusion (CTP) in determining graft patency as well as ... more
by Ikuko Suzuki, Yoshiyuki Tsuboi, Masamichi Shinoda, Kazuo Shibuta, Kuniya Honda, Ayano Katagiri, Masaaki Kiyomoto, Barry J. Sessle, Shingo Matsuura, Kinuyo Ohara, Kentaro Urata, Koichi Iwata To evaluate the involvement of the mitogen-activated protein kinase (MAPK) cascade in o ... more
Increased Rate of Arterial Stiffening with Obesity in Adolescents: A Five-Year Follow-Up Study
by Frida Dangardt, Yun Chen, Krister Berggren, Walter Osika, Peter Friberg Background We prospectively and longitudinally determined the effects of childhood obesity on arterial stiffening and vascular wall changes. Changes in arterial stiffness measured as pulse wave velocity (PWV) and ... more
Genetic variants associated with caffeine intake identified
Two genes in which variation affects intake of caffeine, the most widely consumed stimulant in the world, have been discovered. A team of investigators from the National Cancer Institute, Harvard School of Public Health, Brigham and Women's Hospital, and the University of North Carolina at ... more
Did seasonal flu vaccination increase the risk of infection with pandemic H1N1 flu?
In September 2009, news stories reported that researchers in Canada had found an increased risk of pandemic H1N1 (pH1N1) influenza in people who had previously been vaccinated against seasonal influenza. Their research, consisting of four different studies, has now undergone further scienti ... more
Characterization of grapevine transposons furthers understanding of in vino variety
The grapevine (Vitis vinifera) is a widely cultivated crop that has been subjected to intensive breeding since the Neolithic period (from ~10,500 to ~6,000 years ago). The domestication of grapevine has undergone a selection for traits important for its cultivation and usage. The recent pu ... more
Über CHEMIE.DE
CHEMIE.DE Information Service GmbH runs specialist scientific internet portals. The secret to our success? We are familiar with what we publish.
Advertising at CHEMIE.DE
Our advertising formats support you in getting your message across to a clearly defined target audience.
© 1997-2013 CHEMIE.DE Information Service GmbH, All rights reserved
Netmeeting
