my.bionity.com
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
ABSTRACT Objective
We examined the outcomes of pregnancies in which the fetal head circumference (HC) was below the 5th centile at the routine second‐trimester scan.
Materials and MethodsWe retrospectively analysed outcomes of 18 377 women according to HC Z scores at second‐trimester ultrasound examination between 2001 and 2008. We collected all major malformations, intrauterine deaths and other abnormal outcomes.
ResultsSix hundred seventy‐four fetuses (3.7%) had an HC below the 5th centile. Twenty‐one major malformations were noted, consisting mainly of neurological abnormalities (3.1%). There were seven intra uterine fetal death (1.3%). Of all the fetuses, 26% were lost to follow‐up. Outcome and neurological development was normal in 467 cases, based on neonatal examination and/or parent or general practitioner reports. Major abnormalities were noted in respectively 26.2%, 3.0% and 1.1% of fetuses with Z scores < −2.5, ‐2.5 to −2.0, and −2 to −1.645, compared with 0.3% of fetuses with normal HC (p < 10–4).
ConclusionA head circumference below the 5th centile at second‐trimester scan is associated with various abnormalities, especially neurological disorders. The outcome was worse when the HC was smaller. An HC Z score below −2.5 was strongly associated with neurological and chromosomal abnormalities. Conversely, an HC Z score below −1.645 but above −2, excluding cases with prenatally diagnosed malformations, seems to be reassuring for favorable neonatal outcome. © 2012 John Wiley & Sons, Ltd.
| Authors: | Benjamin Deloison, Gihad E. Chalouhi, Jean‐Pierre Bernard, Yves Ville, Laurent J. Salomon | |
| Journal: | Prenatal Diagnosis | |
| Year: | 2012 | |
| Pages: | 1 | |
| DOI: | 10.1002/pd.3923 | |
| Publication date: | 13-06-2012 |
Watchlist
This is where you can add this publication to your personal favourites.
Additional Information
Cancer risks for MLH1 and MSH2 mutation carriers
ABSTRACT We studied 17,576 members of 166 MLH1 and 224 MSH2 mutation‐carrying families from the Colon Cancer Family Registry. Average cumulative risks of colorectal cancer (CRC), endometrial cancer (EC) and other cancers for carriers were estimated using modified segregation analysis co ... more
Scope Flavonoids have well‐known antioxidant, anti‐inflammatory, and anti‐cancer activities. Isoflavone genistein is considered a potent antioxidant agent against oxidative stress. Although several mechanisms have been proposed, a clear antioxidant mechanism of genistein is still remain ... more
Abstract People can get oral cancers from UV (290‐400 nm) exposures. Besides high outdoor UV exposures, high indoor UV exposures to oral tissues can occur when consumers use UV‐emitting tanning devices to either tan or whiten their teeth. We compared the carcinogenic risks of skin to or ... more
Marijuana use may increase risk of testicular cancer
A new study from the University of Southern California (USC) has found a link between recreational marijuana use and an increased risk of developing subtypes of testicular cancer that tend to carry a somewhat worse prognosis. Published in CANCER the findings suggest that the potential cance ... more
New Study into Bladder Regeneration Heralds Organ Replacement Treatment
Researchers in the United States have developed a medical model for regenerating bladders using stem cells harvested from a patient’s own bone marrow. The research, published in STEM CELLS, is especially relevant for paediatric patients suffering from abnormally developed bladders, but also ... more
Stem Cells journal awards human cord-blood research
The journal Stem Cells has announced Dr. Cinzia Rota as the winner of the annual Stem Cells Young Investigator Award. Co-sponsored by the International Stem Cell Symposium, the $10,000 prize is annually given to a young scientist who is the principal author of a research paper published in ... more
Über CHEMIE.DE
CHEMIE.DE Information Service GmbH runs specialist scientific internet portals. The secret to our success? We are familiar with what we publish.
Advertising at CHEMIE.DE
Our advertising formats support you in getting your message across to a clearly defined target audience.
© 1997-2013 CHEMIE.DE Information Service GmbH, All rights reserved
Netmeeting
