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Cirrhosis is a common and terminal outcome of many chronic liver conditions. A urinary metabonomic study using gas chromatography–mass spectrometry (GC–MS) and ultra performance liquid chromatography time-of-flight mass spectrometry (UPLC–TOFMS) was carried out to elucidate the pathophysiological basis of posthepatitis B cirrhosis in 63 posthepatitis B cirrhosis patients and 31 health controls. Urinary metabolic profile and corresponding differential metabolites associated with Child-Pugh (CP) grading of liver function were characterized, in addition to the blood routine, liver, and renal function tests. Multivariate statistical tools including principal component analysis (PCA) and orthogonal partial least-squares-discriminant analysis (OPLS-DA) were employed in the metabolite analysis along with a univariate statistical method, Wilcoxon–Mann–Whitney test. The alterations of differential metabolites contributing to the intergroup variation between healthy controls and cirrhotic patients, and among cirrho...
| Authors: | Xiaoning Wang; Xiaoyan Wang; Guoxiang Xie; Mingmei Zhou; Huan Yu; Yan Lin; Guangli Du; Guoan Luo; Wei Jia; Ping Liu | |
| Journal: | Journal of Proteome Research | |
| Year: | 2012 | |
| DOI: | 10.1021/pr300337s | |
| Publication date: | 07-06-2012 |
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