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Nestled in an industrial sprawl at the foot of California’s San Bruno Mountain, the biotechnology firm Genentech faces the steel-gray waters of the San Francisco Bay. From his perch in the postcard-worthy campus, National Academy of Sciences member Ira Mellman has presided over a small cadre of cancer biologists for nearly half a decade. When Mellman became vice president of research oncology at the firm in 2007, he was already a household name among the world’s leading cell biologists thanks to his discovery of microscopic vesicles called endosomes, which shuttle proteins between compartments within cells. Over the years, he has...
| Authors: | Prashant Nair | |
| Journal: | Proceedings of the National Academy of Sciences current issue | |
| Volume: | 109 | |
| Issue: | 23 | |
| Year: | 2012 | |
| Pages: | 8790 | |
| DOI: | 10.1073/pnas.1207791109 | |
| Publication date: | 05-06-2012 |
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The time required to recover from cold-induced paralysis (chill-coma) is a common measure of insect cold tolerance used to test central questions in thermal biology and predict the effects of climate change on insect populations. The onset of chill-coma in the fall field cricket (Gryllus pe ... more
Forecasting seasonal outbreaks of influenza [Applied Mathematics]
Influenza recurs seasonally in temperate regions of the world; however, our ability to predict the timing, duration, and magnitude of local seasonal outbreaks of influenza remains limited. Here we develop a framework for initializing real-time forecasts of seasonal influenza outbreaks, usin ... more
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