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Abstract
More than 400,000 primary hip and knee replacement surgeries are performed each year in the United States. From these procedures, approximately 0.5–3% will become infected and when considering revision surgeries, this rate has been found to increase significantly. Antibiotic‐resistant bacterial infections are a growing problem in patient care. This in vitro research investigated the antimicrobial potential of the polymer released, broad spectrum, Cationic Steroidal Antimicrobial‐13 (CSA‐13) for challenges against 5 × 108 colony forming units (CFU) of methicillin‐resistant Staphylococcus aureus (MRSA). It was hypothesized that a weight‐to‐weight (w/w) concentration of 18% CSA‐13 in silicone would exhibit potent bactericidal potential when used as a controlled release device coating. When incorporated into a polymeric device coating, the 18% (w/w) broad‐spectrum polymer released CSA‐13 antimicrobial eliminated 5 × 108 CFU of MRSA within 8 h. In the future, these results will be utilized to develop a sheep model to assess CSA‐13 for the prevention of perioperative device‐related infections in vivo. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.
| Authors: | K. D. Sinclair, T. X. Pham, R. W. Farnsworth, D. L. Williams, C. Loc‐Carrillo, L. A. Horne, S. H. Ingebretsen, R. D. Bloebaum | |
| Journal: | Journal of Biomedical Materials Research Part A | |
| Year: | 2012 | |
| Pages: | n/a | |
| DOI: | 10.1002/jbm.a.34209 | |
| Publication date: | 24-05-2012 |
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