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In a search for natural phytoestrogens, 130 traditional Chinese medicinal extracts related to gynecological disorders were investigated by the Arabidopsis pER8:GUS reporter assay system. The EtOH extract of Cuscuta chinensis showed estrogenic activity (100 μg/mL) and affored three new lignans, cuscutaresinols A–C (1–3), and 16 known compounds. Cuscutaresinols A–C (1–3), (+)-sesamin (4), (+)-xanthoxylol (5), 9-hydroxysesamin (6), (+)-pinoresinol (7), kaempferol (8), and isorhamnetin (9) showed estrogenic activity, with 8 and 9 exhibiting the most potent activity. Kaempferol (8) and isorhamnetin (9) are the major components of C. chinenesis EtOH extract and the key contributors to its estrogenic activity in the Arabidopsis pER8:GUS reporter assay system.
| Authors: | Yu-Chi Tsai; Wan-Chun Lai; Ying-Chi Du; Shou-Fang Wu; Mohamed El-Shazly; Chia-Lin Lee; Ming-Hong Yen; Ming-Feng Hou; Yang-Chang Wu; Fang-Rong Chang | |
| Journal: | Journal of Natural Products | |
| Year: | 2012 | |
| DOI: | 10.1021/np200974e | |
| Publication date: | 25-05-2012 |
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