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Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis. CAPE effectively reduced both histamine and serotonin (5-HT)-induced vascular permeability in rats. CAPE also reduced histamine and leukotrienes (LTs) release from isolated rat peritoneal mast cells. Moreover, CAPE suppressed contraction induced by histamine (3 × 10−8–3 × 10−5 M), 5-HT (3 × 10−9–10−6 M) and adenosine (3 × 10−8–10−5 M) in guinea pig tracheal zigzag. These findings provide evidence that CAPE may serve as an effective therapeutic agent for allergic diseases.
| Authors: | Manar A. Nader | |
| Journal: | Inflammopharmacology | |
| Year: | 2012 | |
| DOI: | 10.1007/s10787-012-0138-4 | |
| Publication date: | 19-05-2012 |
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