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Detailed structural characterization of protein–polymer conjugates and understanding of the interactions between covalently attached polymers and biomolecules will build a foundation to design and synthesize hybrid biomaterials. Conjugates based on simple protein structures are ideal model system to achieve these ends. Here we present a systematic structural study of coiled-coil peptide–poly(ethylene glycol) (PEG) side-conjugates in solution, using circular dichroism, dynamic light scattering, and small-angle X-ray scattering, to determine the conformation of conjugated PEG chains. The overall size and shape of side-conjugates were determined using a cylindrical form factor model. Detailed structural information of the covalently attached PEG chains was extracted using a newly developed model where each peptide–PEG conjugate was modeled as a Gaussian chain attached to a cylinder, which was further arranged in a bundle-like configuration of three or four cylinders. The peptide–polymer side-conjugates were ...
| Authors: | Jessica Y. Shu; Reidar Lund; Ting Xu | |
| Journal: | Biomacromolecules | |
| Year: | 2012 | |
| DOI: | 10.1021/bm300561y | |
| Publication date: | 18-05-2012 |
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