Future Neurology , January 2013, Vol. 8, No. 1, Pages 13-16. more
To use all functions of this page, please activate cookies in your browser.
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
Aims: To determine whether there is an association between CFH, ARMS2, HTRA1, VEGF, SERPING1 or C3 genotypes and patient response to treatment with intravitreal bevacizumab for neovascular age-related macular degeneration (AMD). Materials & methods: This was a multicenter prospective study. One hundred and forty four patients with neovascular AMD treated with bevacizumab were recruited from 13 centers. Twelve SNPs were genotyped using Sequenom. Visual acuity score (VAS), central retinal thickness and maximum thickness of lesion were measured at each visit. Results: For the CFH rs800292 polymorphism, mean VAS changes were 4.4, 8.7 and 15.5 letters in the CC, CT and TT genotype carriers (p = 0.009). For ARMS2 rs10490924, mean VAS changes were 3.6, 12.1 and 9.6 letters for the TT, TG and GG genotypes (p = 0.001). For HTRA1 rs11200638, mean VAS changes were 3.6, 12.3 and 9.6 letters for the AA, AG and GG genotypes (p < 0.001). Conclusion: CFH, ARMS2 and HTRA1 genotypes may influence patient response to treatm...
|Authors:||Jun Tian; Xueying Qin; Kai Fang; Qing Chen; Jing Hou; Juan Li; Wenzhen Yu; Dafang Chen; Yonghua Hu; Xiaoxin Li|
This is where you can add this publication to your personal favourites.
Future Neurology , January 2013, Vol. 8, No. 1, Pages 5-7. more
Future Neurology , January 2013, Vol. 8, No. 1, Pages 1-3. more