my.bionity.com
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
We review the optical properties, fabrication, and applications of zero-mode waveguides (ZMWs) for single-molecule studies. These simple nano-structures allow individual molecules to be isolated for optical analysis at high concentrations. Fluorescent species are observed in a sufficiently small volume that the average number of fluorescent molecules is less than one, even at concentrations high enough for biochemical reactions to proceed at normal rates. Arrays of such structures can also be engineered into systems for real-time analysis of large numbers of single-molecule reactions or binding events. We also review the integration of ZMWs in different optical configurations and microfluidic systems.
| Authors: | Paul Zhu; Harold G. Craighead | |
| Journal: | Annual Review of Biophysics | |
| Year: | 2012 | |
| DOI: | 10.1146/annurev-biophys-050511-102338 | |
| Publication date: | 11-05-2012 |
Watchlist
This is where you can add this publication to your personal favourites.
Additional Information
The Role of Mountain Ranges in the Diversification of Birds
Avian faunas vary greatly among montane areas; those at high latitudes are biologically impoverished, whereas those of some low-latitude mountains are biologically very complex. Their high level of species richness is caused by the aggregation of many small-ranged species, which has been di ... more
Inflammation: Mechanisms, Costs, and Natural Variation
Inflammation is a pervasive phenomenon that operates during severe perturbations of homeostasis, such as infection, injury, and exposure to contaminants, and is triggered by innate immune receptors that recognize pathogens and damaged cells. Among vertebrates, the inflammatory cascade is a ... more
From Animalcules to an Ecosystem: Application of Ecological Concepts to the Human Microbiome
The human body is inhabited by billions of microbial cells and these microbial symbionts play critical roles in human health. Human-associated microbial communities are diverse, and the structure of these communities is variable across body habitats, through time, and between individuals. W ... more
Über CHEMIE.DE
CHEMIE.DE Information Service GmbH runs specialist scientific internet portals. The secret to our success? We are familiar with what we publish.
Advertising at CHEMIE.DE
Our advertising formats support you in getting your message across to a clearly defined target audience.
© 1997-2013 CHEMIE.DE Information Service GmbH, All rights reserved
Publications
Netmeeting
