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Abstract
GdX (also named Ubl4A) is a house‐keeping gene located on the X chromosome and encodes a protein harboring an ubiquitin‐like domain in human and mouse. Although identified in 1988, the function of GdX remains unknown. To elucidate the role of GdX in vivo, we generated a conditional GdX knockout mouse in which Exon 2 was flanked by two loxP sites. We obtained viable and fertile mice with homozygous GdXflox/flox or GdXflox/Y allele. Germ‐line transmission was confirmed by crossing the mouse bearing conditionally targeted allele with an EIIα‐Cre transgenic mouse. GdX was successfully depleted in tissues of EIIα‐Cre‐GdX‐null mice. GdX−/− and GdX−/Y mice are viable and exhibit normal development compared with wild‐type littermates within 6 months during our observation. We also observed that GdX knockout male mice were functionally normal in the reproductive system where Ubl4B was specifically expressed. GdXflox/flox and GdXflox/Y conditional mice provide a tool for further tissue‐specific function analysis of the GdX protein under different conditions. genesis 00:1–9, 2012. © 2012 Wiley Periodicals, Inc.
| Authors: | Wang, Yangmeng; Wang, Dianjun; Ren, Fangli; Zhang, Yuanjiang; Lin, Fuyu; Hou, Ning; Cheng, Xuan; Zhang, Peng; Wang, Yinyin; Jia, Baoqing; Yang, Xiao; Chang, Zhijie | |
| Journal: | genesis | |
| Year: | 2012 | |
| Pages: | n/a | |
| DOI: | 10.1002/dvg.20832 | |
| Publication date: | 24-01-2012 |
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