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Abstract
Studies in animals and in healthy volunteers have demonstrated the central serotonergic analgesic mechanism of action of paracetamol involving the inhibition of this analgesia by tropisetron, a 5‐HT3 antagonist. This randomized, double‐blind, controlled study aims at studying this interaction in post‐operative patients after ear surgery. Thirty‐six patients are included in two parallel groups with intravenous paracetamol (1 g) and either tropisetron (T, 5 mg/mL) or placebo (c, NaCl 0.9%) administered at the end of surgery. Numerical pain evaluations are performed every 30 min, six times after awakening. The difference between the sums of numerical scales of both groups [9 ± 10 (T) vs. 6 ± 7 (c)] is not significant, but the tropisetron group displays higher pain scores despite additional rescue analgesia. The limits of this trial call for a much larger study to investigate further this pharmacodynamic interaction.
| Authors: | Pickering, Gisèle; Faure, Michael; Commun, Fabienne; de Boissy, Elisabeth Carrier; Roche, Ghislaine; Mom, Thierry; Simen, Estelle; Dubray, Claude; Eschalier, Alain; Gilain, Laurent | |
| Journal: | Fundamental & Clinical Pharmacology | |
| Volume: | 26 | |
| Issue: | 3 | |
| Year: | 2012 | |
| Pages: | 432 | |
| DOI: | 10.1111/j.1472-8206.2011.00933.x | |
| Publication date: | 01-06-2012 |
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