Metabonomics study of the acute graft rejection in rat renal transplantation using reversed-phase liquid chromatography and hydrophilic interaction chromatography coupled with mass spectrometry

Urea in Aqueous Solution studied by Quantum Mechanical Charge Field - Molecular Dynamics (QMCF-MD)

This work presents a quantum mechanical charge field - molecular dynamics (QMCF-MD) simulation of urea in dilute aqueous solution. Detailed data on structure and dynamics are provided and compared to previous work of other groups. Radial and angular distributions are employed, as well as hig ... more

Identification of Calcium binding sites on calsequestrin 1 and its implications to polymerization

Biophysical studies have shown that each molecule of calsequestrin 1 (CASQ1) can bind about 70-80 Ca2+ ions. However, the nature of Ca2+-binding sites has not yet been fully characterized. In this study, we employed in-silico approaches to identify the Ca2+ binding sites and to understand t ... more

Human Cathelicidin Peptide LL37 Binds Telomeric G-Quadruplex

The G-rich strand of human telomeric DNA folds to adopt very stable G-Quadruplex structure. Formation and stabilization of G-Quadruplex inhibit the activity of the enzyme telomerase in cancer cell. In this present study we used four different G-rich sequence of human telomeric DNA, which fo ... more

High throughput phenotyping of uropathogenic E. coli isolates with Fourier transform infrared spectroscopy

UK scientists have designed a high throughput method to determine the phenotypes of the different Escherichia coli strains that cause urinary tract infections. The method couples bacterial growth requirements to Fourier transform infrared spectroscopy. The majority of urinary tract infectio ... more

Self-powered herbicide biosensor

A self-powered biosensor that can detect herbicides in water has been developed by US scientists. Most commercial herbicides act by inhibiting photosynthesis in plants. Unfortunately, photosynthetic aquatic microorganisms and aquatic plants are also similarly affected, which is why herbicid ... more

Ionic liquids could aid in the delivery of active pharmaceutical compounds in the body

US scientists have provided a strategy to improve the properties of active pharmaceutical ingredients (APIs) by combining ionic liquids (used to improve the properties of solid APIs) with prodrugs (used to improve solubility, permeability and bioavailability of APIs). The prodrug ionic liqu ... more