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Large mtDNA deletions in mouse brain and spleen cells, induced by X-radiation at doses of 2 and 5 Gy were studied within four weeks after the exposure of animals to X-rays. Variations in the content of extra-cellular deleted mtDNA were examined in the blood plasma of mice irradiated with 5 Gy in the same postir-radiation times. Ionizing radiation was shown to effectively induce large mtDNA deletions at the doses chosen. The level of deletion mtDNA was dependent on dose and postirradiation time.
| Authors: | V. N. Antipova, L. V. Malakhova, V. G. Bezlepkin | |
| Journal: | Biophysics | |
| Year: | 2011 | |
| DOI: | 10.1134/S0006350911030031 | |
| Publication date: | 22-08-2011 |
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