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Abscission accomplished by PtdIns(3)P
Nature Cell Biology 12, 308 (2010). doi:10.1038/ncb0410-308
Authors: Guillaume Montagnac & Philippe Chavrier
Cytokinesis — the final step of mitosis in which the two daughter cells separate — requires accumulation of specific proteins and lipids at the connecting bridge to ensure cleavage by abscission. Phosphatidylinositol-3-phosphate (PtdIns(3)P), an endosomal phosphoinositide, and FYVE-CENT, a PtdIns3P-binding protein, are found in the bridge, where they contribute to the mechanism of abscission.
| Authors: | Guillaume Montagnac; Philippe Chavrier | |
| Journal: | Nature Cell Biology | |
| DOI: | 10.1038/ncb0410-308 |
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