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Abstract This work presents a characterization of the stoichiometry and kinetics of anaerobic batch growth of Saccharomyces cerevisiae at cultivation temperatures between 12 and 30°C. To minimize the influence of the inoculum condition and ensure full adaptation to the cultivation temper ... more
Abstract A new methodology to use efficiently flue gases as CO2 source in the production of photosynthetic microorganisms is proposed. The CO2 is absorbed in an aqueous phase that is then regenerated by microalgae. Carbonated solutions could absorb up to 80% of the CO2 from diluted gas r ... more
Abstract In HIV infections, homoeostasis of T cells is dysregulated such that there is a depletion of CD4+ T cells and a progressive loss of naïve CD4+ and CD8+ T cells. Methodologies that can improve the function of some or all of these cells will likely enhance immune responsiveness in ... more
ABSTRACT The atrial natriuretic peptide (ANP) and its precursor (N‐terminal fragment of atrial natriuretic peptide, NT‐proANP) are natriuretic peptides released into the circulation as a consequence of an acute atrial stretch. As for the brain natriuretic peptide and its N‐terminal fragm ... more
ABSTRACT Wistar rats were nose‐only exposed to pigment‐sized iron oxide dust (Fe3O4, magnetite) in a subchronic 13‐week inhalation study according to the OECD testing guidelines TG#413 and GD#39. A 4 week pilot study with a 6 month post exposure period served as basis for validating the ... more
Abstract This work presents a characterization of the stoichiometry and kinetics of anaerobic batch growth of Saccharomyces cerevisiae at cultivation temperatures between 12 and 30°C. To minimize the influence of the inoculum condition and ensure full adaptation to the cultivation temper ... more
Abstract A new methodology to use efficiently flue gases as CO2 source in the production of photosynthetic microorganisms is proposed. The CO2 is absorbed in an aqueous phase that is then regenerated by microalgae. Carbonated solutions could absorb up to 80% of the CO2 from diluted gas r ... more
Abstract In HIV infections, homoeostasis of T cells is dysregulated such that there is a depletion of CD4+ T cells and a progressive loss of naïve CD4+ and CD8+ T cells. Methodologies that can improve the function of some or all of these cells will likely enhance immune responsiveness in ... more
Abstract Mesophilic glucuronidases are the most widely used reporters of gene expression in plants, but unsuitable as reporters in (hyper‐)thermophiles due their insufficient thermal stability. Here we present the native 66.8 kDa thermostable β‐glucuronidase of Sulfolobus solfataricus. T ... more
Abstract Many enzymatic reactions are near‐equilibrium reactions. This often limits final yield and hence application of biocatalyzed processes in the industrial production. The most widely applied strategy to overcome this issue is solvent selection. It must be underlined that measuring ... more
ABSTRACT Objective Ventriculomegaly (VM) is the most common brain anomaly in prenatal ultrasound (US) diagnosis. There is a general trend to perform fetal magnetic resonance imaging (MRI) when VM is severe (greater than 15 mm) and/or it is not isolated. The role of MRI is debated when ... more
ABSTRACT Objectives To investigate the levels of tumour markers CA 19–9 and CA 15–3 in the first trimester maternal serum of euploid control and trisomy 21 pregnancies. Methods Maternal serum marker levels of 69 trisomy 21 and 388 euploid controls were quantified by the Kryptor a ... more
ABSTRACT Objective The aim of this study was to determine service users' experiences of and preferences for service delivery of fetal sex determination by noninvasive prenatal diagnosis (NIPD) using cell‐free fetal DNA. Methods We used a qualitative approach using semistructured ... more
ABSTRACT Objective The aim of this study is to determine the effect of interrupting prenatal Down syndrome screening for women with large nuchal translucency (NT) measurements on the performance of combined and integrated tests. Design Distribution of large NT at 11–13 weeks of g ... more
ABSTRACT Objective Here we describe the successful application of massively parallel sequencing for noninvasive prenatal detection of trisomy 21. In addition, for the detection of a broader spectrum of fetal aneuploidies, a target enrichment approach was successfully tested. Method ... more
Ferroportin-1 is a ‘nuclear’-negative acute-phase protein in rat liver: a comparison with other iron-transport proteins Laboratory Investigation advance online publication, April 2, 2012. doi:10.1038/labinvest.2012.52 Authors: Naila Naz, Ihtzaz A Malik, Nadeem Sheikh, Shakil ... more
Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis Laboratory Investigation advance online publication, March 12, 2012. doi:10.1038/labinvest.2012.45 Authors: Laura J Dixon, Michael Berk, Samjhana Thapaliya, Bettina G Papouchado ... more
Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms Laboratory Investigation advance online publication, February 13, 2012. doi:10.1038/labinvest.2012.9 Authors: Kei Sakamoto, Takuma Fujii, Hiroshi Kawachi, Yoshio Miki, ... more
Inside Lab Invest Laboratory Investigation 92, 164 (February 2012). doi:10.1038/labinvest.2011.202 more
Inhibition of Gsk3β activity improves β-cell function in c-KitWv/+ male mice Laboratory Investigation advance online publication, January 16, 2012. doi:10.1038/labinvest.2011.200 Authors: Zhi-Chao Feng, Lisa Donnelly, Jinming Li, Mansa Krishnamurthy, Matthew Riopel ... more
Summary What is known and Objective: Psychotherapy has traditionally competed with psychopharmacology. As drugs have become the more dominant treatment in psychiatry and primary care, this approach is increasingly criticized as limited in scope, lacking in robust outcomes and too heavil ... more
Abstract A national war formulary, published during the Second World War, was succeeded by hardback books called British National Formularies (BNFs), which were produced by the British Medical Association and the Royal Pharmaceutical Society about every 3 years until 1976. In 1981 a grea ... more
Abstract A computational model for estimating dermal clearance in humans of arbitrary, nonmetabolized solutes is presented. The blood capillary component employs slit theory with contributions from both small (10 nm) and large (50 nm) slits. The lymphatic component is derived from previo ... more
Abstract Clinical toxicology concerns the investigation, diagnosis, and management of suspected poisoning. It is an important discipline, because of the frequency of suspected poisoning, including drug overdose. In the UK most episodes are managed by non‐specialists, with support provide ... more
Abstract Furosemide (FS) is a potent loop diuretic widely used in the management of fluid retention associated with cardiac, renal, and hepatic failure as well as for the treatment of hypertension. FS is a well‐characterized and known hepatotoxin in both human and animal test systems. In ... more
ABSTRACT The atrial natriuretic peptide (ANP) and its precursor (N‐terminal fragment of atrial natriuretic peptide, NT‐proANP) are natriuretic peptides released into the circulation as a consequence of an acute atrial stretch. As for the brain natriuretic peptide and its N‐terminal fragm ... more
ABSTRACT Wistar rats were nose‐only exposed to pigment‐sized iron oxide dust (Fe3O4, magnetite) in a subchronic 13‐week inhalation study according to the OECD testing guidelines TG#413 and GD#39. A 4 week pilot study with a 6 month post exposure period served as basis for validating the ... more
Abstract Hyponatremia is a metabolic disorder characterized by increased cerebrospinal fluid (CSF) volume and pressure, although the site of brain insult is unclear. Specifically, the hippocampus, which is in direct contact with expanding CSF ventricles, may be involved. The present stud ... more
Abstract Transplantation of autologous Schwann cells (SCs) is a promising approach for treating various peripheral nerve disorders, including chronic denervation. However, given their drawbacks, such as invasive biopsy and lengthy culture in vitro, alternative cell sources would be neede ... more
ABSTRACT Autophagy is a critical cellular process orchestrating the lysosomal degradation of cellular components in order to maintain cellular homeostasis and respond to cellular stress. A growing research effort over the last decade has proven autophagy to be essential for constitutive ... more
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