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Publications

Search for science publications by its title or author and refine your search on the basis of publishing houses, year etc.

Current publications

A novel BCMA|[sol]|CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo Leukemia advance online publication, January 13 2017. doi:10.1038/leu.2016.388 Authors: S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Ratte ... more

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Leukemia advance online publication, January 3 2017. doi:10.1038/leu.2016.352 Authors: E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeyc ... more

MicroRNA-590-5p regulates cell viability, apoptosis, migration and invasion of renal cell carcinoma cell lines through targeting ARHGAP24

Renal cell carcinoma (RCC) is the leading cause of death in renal malignancies. MicroRNA-590-5p (miR-590-5p) is of great importance in the processes of many cancers regarding regulation of cancer cell invasion and proliferation. In our study, alternation of miR-590-5p expression in RCC cell ... more

A computational method using differential gene expression to predict altered metabolism of multicellular organisms

Altered metabolism is often identified as a cause or an effect of physiology and pathogenesis. But it is difficult to predict the metabolic flux distributions of multicellular organisms due to the lack of an explicit metabolic objective function. Here we present a computational method which ... more

Self-peeling of impacting droplets

Self-peeling of impacting droplets Nature Physics, Published online: 11 September 2017; doi:10.1038/nphys4252 When molten tin droplets impact clean substrates, they either stick or spontaneously detach depending on the substrate temperature. Competition between heat extraction and fluidit ... more

All publications

miR‐200c‐3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment

Abstract Oral squamous cell carcinoma (OSCC) constitutes over 90% of all cancers in the oral cavity. The prognosis for patients with invasive OSCC is poor; therefore, it is important to understand the molecular mechanisms of invasion and subsequent metastasis not only to prevent cancer ... more

The TAD-pathway for GWAS signals

The TAD-pathway for GWAS signals European Journal of Human Genetics, Published online: 12 October 2017; doi:10.1038/ejhg.2017.148 more

Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways [RESEARCH]

Transcriptional deregulation of oncogenic pathways is a hallmark of cancer and can be due to epigenetic alterations. 5-Hydroxymethylcytosine (5-hmC) is an epigenetic modification that has not been studied in pancreatic cancer. Genome-wide analysis of 5-hmC-enriched loci with hmC-seal was co ... more

Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis [METHOD]

The impact of inherited genetic variation on gene expression in humans is well-established. The majority of known expression quantitative trait loci (eQTLs) impact expression of local genes (cis-eQTLs). More research is needed to identify effects of genetic variation on distant genes (trans ... more

Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes [RESEARCH]

Genome-wide association studies (GWAS) have identified multiple, shared allelic associations with many autoimmune diseases. However, the pathogenic contributions of variants residing in risk loci remain unresolved. The location of the majority of shared disease-associated variants in noncod ... more

All publications on biotechnology

A systematic review and meta‐analysis on fetal ovarian cysts: impact of size, appearance and prenatal aspiration.

Abstract Objective To compare outcomes of ultrasound‐guided aspiration of fetal ovarian cysts with conservative management. Method A systematic review of MEDLINE and Web of Science included studies reporting outcomes (pre‐ and post‐natal torsion, spontaneous resolution, and surg ... more

On the road to replacing invasive testing with cell‐based NIPT: five clinical cases with aneuploidies, microduplication, unbalanced structural rearrangement or mosaicism

Abstract Objective Trophoblastic fetal cells harvested from maternal blood have the capacity to be used for copy number analyses in a non‐invasive prenatal test (cbNIPT). Potentially this will result in increased resolution for detection of subchromosomal aberrations due to high qualit ... more

The association between anticoagulation therapy, maternal characteristics, and a failed cfDNA test due to a low fetal fraction

Abstract Objectives The objective of this study was to identify maternal characteristics associated with a failed cell‐free DNA (cfDNA) test due to a low fetal fraction (FF). Method Retrospective cohort study of women with singleton pregnancies who had cfDNA screening at 10‐25 w ... more

Group genetic counseling: an alternate service delivery model in a high risk prenatal screening population

Abstract Objective To address the growing demand for prenatal genetics services, group genetic counseling was explored as an alternative service delivery model for women with a positive prenatal screening result. Method Women were recruited from a prenatal genetics service and s ... more

The amniotic fluid as a source of mesenchymal stem cells with lung‐specific characteristics

Abstract The amniotic fluid is a clinically accessible source of mesenchymal stem cells (AF‐MSC) during gestation, which enables autologous cellular therapy for perinatal disorders. The origin of AF‐MSC remains elusive: renal and neuronal progenitors have been isolated from the AF‐MSC po ... more

All publications on diagnostics

New targets bring hope in squamous cell lung cancer: neurotrophic tyrosine kinase gene fusions

New targets bring hope in squamous cell lung cancer: neurotrophic tyrosine kinase gene fusions New targets bring hope in squamous cell lung cancer: neurotrophic tyrosine kinase gene fusions, Published online: 31 October 2017; doi:10.1038/labinvest.2017.91 more

ResolvinD1 stimulates epithelial wound repair and inhibits TGF-β-induced EMT whilst reducing fibroproliferation and collagen production

ResolvinD1 stimulates epithelial wound repair and inhibits TGF-β-induced EMT whilst reducing fibroproliferation and collagen production ResolvinD1 stimulates epithelial wound repair and inhibits TGF-β-induced EMT whilst reducing fibroproliferation and collagen production, Published online: ... more

Metastasis suppressors: functional pathways

Metastasis suppressors: functional pathways Laboratory Investigation, Published online: 2 October 2017; doi:10.1038/labinvest.2017.104 more

Assessment of tumor characteristics based on glycoform analysis of membrane-tethered MUC1

Assessment of tumor characteristics based on glycoform analysis of membrane-tethered MUC1 Laboratory Investigation 97, 1262 (October 2017). doi:10.1038/labinvest.2017.67 Authors: Atsushi Matsuda, Michiyo Higashi, Tomomi Nakagawa, Seiya Yokoyama, Atsushi Kuno, Suguru Yo ... more

Multiplexed ion beam imaging analysis for quantitation of protein expresssion in cancer tissue sections

Multiplexed ion beam imaging analysis for quantitation of protein expresssion in cancer tissue sections Laboratory Investigation 97, 1263 (October 2017). doi:10.1038/labinvest.2017.94 Authors: Sandra Rost, Jennifer Giltnane, Jennifer M Bordeaux, Chuck Hitzman, Hartmut ... more

All publications on lab technology

Utilizing Inverse Emulsion Polymerization To Generate Responsive Nanogels for Cytosolic Protein Delivery

Therapeutic biologics have various advantages over synthetic drugs in terms of selectivity, their catalytic nature, and, thus, therapeutic efficacy. These properties offer the potential for more effective treatments that may also overcome the undesirable side effects observed due to off-tar ... more

Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol Dependent Rats and Humans

Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol Dependent Rats and Humans Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol Dependent Rats and Humans, Published online: 01 November 2017; doi:10.1038/npp.2017.257 more

Marine Drugs, Vol. 15, Pages 341: Cucumarioside A2-2 Causes Macrophage Activation in Mouse Spleen

Marine Drugs, Vol. 15, Pages 341: Cucumarioside A2-2 Causes Macrophage Activation in Mouse Spleen Marine Drugs doi: 10.3390/md15110341 Authors: Evgeny Pislyagin Igor Manzhulo Tatiana Gorpenchenko Pavel Dmitrenok Sergey Avilov Alexandra Silchenko Yun-Ming Wang Dmitry Am ... more

Marine Drugs, Vol. 15, Pages 342: Antimicrobial and Anti-Proliferative Effects of Skin Mucus Derived from Dasyatis pastinaca (Linnaeus, 1758)

Marine Drugs, Vol. 15, Pages 342: Antimicrobial and Anti-Proliferative Effects of Skin Mucus Derived from Dasyatis pastinaca (Linnaeus, 1758) Marine Drugs doi: 10.3390/md15110342 Authors: Virginia Fuochi Giovanni Li Volti Giuseppina Camiolo Francesco Tiralongo Cesarina Giall ... more

Marine Drugs, Vol. 15, Pages 338: Isolation and Characterization of Polysaccharides from Oysters (Crassostrea gigas) with Anti-Tumor Activities Using an Aqueous Two-Phase System

Marine Drugs, Vol. 15, Pages 338: Isolation and Characterization of Polysaccharides from Oysters (Crassostrea gigas) with Anti-Tumor Activities Using an Aqueous Two-Phase System Marine Drugs doi: 10.3390/md15110338 Authors: Kit-Leong Cheong Li-Xuan Xia Yang Liu In this stu ... more

All publications on pharma

A novel BCMA|[sol]|CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo Leukemia advance online publication, January 13 2017. doi:10.1038/leu.2016.388 Authors: S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Ratte ... more

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Leukemia advance online publication, January 3 2017. doi:10.1038/leu.2016.352 Authors: E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeyc ... more

Atherosclerosis: Association between the gut microbiome and atherosclerosis

Atherosclerosis: Association between the gut microbiome and atherosclerosis Atherosclerosis: Association between the gut microbiome and atherosclerosis, Published online: 03 November 2017; doi:10.1038/nrcardio.2017.169 NatureArticleSnippet(type=standfirst, markup= The gut microbiota has be ... more

Prognostic value of antigen expression in multiple myeloma: A PETHEMA|[sol]|GEM study on 1,265 patients enrolled in four consecutive clinical trials

Prognostic value of antigen expression in multiple myeloma: A PETHEMA/GEM study on 1,265 patients enrolled in four consecutive clinical trials Prognostic value of antigen expression in multiple myeloma: A PETHEMA/GEM study on 1,265 patients enrolled in four consecutive clinical trials, Pub ... more

Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and pr ...

by Bryony N. Parsons, Umer Z. Ijaz, Rosalinda D’Amore, Michael D. Burkitt, Richard Eccles, Luca Lenzi, Carrie A. Duckworth, Andrew R. Moore, Laszlo Tiszlavicz, Andrea Varro, Neil Hall, D. Mark Pritchard Several conditions associated with reduced gastric acid secretion confer an altered ri ... more

All publications on healthcare
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