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Publications

Search for science publications by its title or author and refine your search on the basis of publishing houses, year etc.

Current publications

A novel BCMA|[sol]|CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo Leukemia advance online publication, January 13 2017. doi:10.1038/leu.2016.388 Authors: S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Ratte ... more

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Leukemia advance online publication, January 3 2017. doi:10.1038/leu.2016.352 Authors: E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeyc ... more

A central role of Cwc25 in spliceosome dynamics during the catalytic phase of pre-mRNA splicing [ARTICLE]

Splicing of precursor mRNA occurs via two consecutive steps of transesterification reaction; both require ATP and several proteins. Despite the energy requirement in the catalytic phase, incubation of the purified spliceosome under proper ionic conditions can elicit competitive reversible t ... more

Structural basis for guanidine sensing by the ykkC family of riboswitches [ARTICLE]

Regulation of gene expression by cis-encoded riboswitches is a prevalent theme in bacteria. Of the hundreds of riboswitch families identified, the majority of them remain as orphans, without a clear ligand assignment. The ykkC orphan family was recently characterized as guanidine-sensing ri ... more

Osmium tetroxide as a probe of RNA structure [REPORT]

Structured RNAs have a central role in cellular function. The capability of structured RNAs to adopt fixed architectural structures or undergo dynamic conformational changes contributes to their diverse role in the regulation of gene expression. Although numerous biophysical and biochemical ... more

All publications

A central role of Cwc25 in spliceosome dynamics during the catalytic phase of pre-mRNA splicing [ARTICLE]

Splicing of precursor mRNA occurs via two consecutive steps of transesterification reaction; both require ATP and several proteins. Despite the energy requirement in the catalytic phase, incubation of the purified spliceosome under proper ionic conditions can elicit competitive reversible t ... more

Structural basis for guanidine sensing by the ykkC family of riboswitches [ARTICLE]

Regulation of gene expression by cis-encoded riboswitches is a prevalent theme in bacteria. Of the hundreds of riboswitch families identified, the majority of them remain as orphans, without a clear ligand assignment. The ykkC orphan family was recently characterized as guanidine-sensing ri ... more

Osmium tetroxide as a probe of RNA structure [REPORT]

Structured RNAs have a central role in cellular function. The capability of structured RNAs to adopt fixed architectural structures or undergo dynamic conformational changes contributes to their diverse role in the regulation of gene expression. Although numerous biophysical and biochemical ... more

The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation [REPORT]

The nuclear poly(A) binding protein (PABPN1) has been suggested, on the basis of biochemical evidence, to play a role in mRNA polyadenylation by strongly increasing the processivity of poly(A) polymerase. While experiments in metazoans have tended to support such a role, the results were no ... more

Involvement of fission yeast Pdc2 in RNA degradation and P-body function [ARTICLE]

In this study we identified Pdc2, the fission yeast ortholog of human Pat1b protein, which forms a complex with Lsm1-7 and plays a role in coupling deadenylation and decapping. The involvement of Pdc2 in RNA degradation and P-body function was also determined. We found that Pdc2 interacts w ... more

All publications on biotechnology

Cryopreserved Human Umbilical Cord vs. Biocellulose Film for Antenatal Spina Bifida Repair in a Physiologic Rat Model

Abstract Background Antenatal spina bifida (SB) repair with a regenerative patch may improve neurological outcomes by decreasing inflammatory scarring. Objective To compare cryopreserved human umbilical cord (HUC) and biocellulose film (BCF) patches sutured over SB lesions for r ... more

Issue Information

No abstract is available for this article. more

Preimplantation genetic haplotyping for six Chinese pedigrees with thalassemia using a single nucleotide polymorphism microarray

Abstract Objective To demonstrate the accuracy and feasibility of using single nucleotide polymorphism (SNP) array‐based preimplantation genetic haplotyping (PGH) in Chinese population, as the currently short tandem repeat (STR) method is labor‐intensive and time‐consuming. Metho ... more

Oxidative damage and nitric oxide synthase induction by surgical uteroplacental circulation restriction in the rabbit fetal heart

Abstract Objective This study investigated the role of oxidative damage and nitric oxide (NO) synthases in the fetal heart using a model of intrauterine growth restriction (IUGR) induced by uteroplacental circulation restriction (UCR). Methods New Zealand white rabbits kept und ... more

Prevalence, timing of diagnosis and pregnancy outcome of abdominal wall defects after the introduction of a national prenatal screening program.

Abstract Objective To examine prevalence, time of diagnosis and outcome of fetuses with an exomphalos or gastroschisis, diagnosed since the introduction of a national prenatal screening program in 2007. Methods A prospective cohort study was undertaken in two fetal medicine unit ... more

All publications on diagnostics

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology Laboratory Investigation advance online publication, March 6 2017. doi:10.1038/labinvest.2017.9 Authors: Akinori Kawakami & David E Fisher more

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 97, 230 (March 2017). doi:10.1038/labinvest.2017.7 more

Regression in primary cutaneous melanoma: etiopathogenesis and clinical significance

Regression in primary cutaneous melanoma: etiopathogenesis and clinical significance Laboratory Investigation advance online publication, February 27 2017. doi:10.1038/labinvest.2017.8 Authors: Phyu P Aung, Priyadharsini Nagarajan & Victor G Prieto more

Drugs with anti-oxidant properties can interfere with cell viability measurements by assays that rely on the reducing property of viable cells

Drugs with anti-oxidant properties can interfere with cell viability measurements by assays that rely on the reducing property of viable cells Laboratory Investigation advance online publication, February 27 2017. doi:10.1038/labinvest.2017.18 Authors: Niraj Shenoy, Mary Stens ... more

Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing

Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing Laboratory Investigation advance online publication, February 20 2017. doi:10.1038/labinvest.2017.5 Authors: Sankhiros Babapoor, Rong Wu, James Koz ... more

All publications on lab technology

Process optimization by use of design of experiments: Application for liposomalization of FK506

Publication date: 1 May 2017 Source:European Journal of Pharmaceutical Sciences, Volume 102 Author(s): Hiroyasu Toyota, Tomohiro Asai, Naoto Oku Design of experiments (DoE) can accelerate the optimization of drug formulations, especially complexed formulas such as those of drugs ... more

Thiazolidinone Constraint Combretastatin Analogs as Novel Antitubulin Agents: Design, Synthesis, Biological Evaluation and Docking Studies

Abstract: Background: Microtubules act as a useful and strategic molecular target for various anticancer drugs that binds to its distinct sites in tubulin subunits and inhibits its polymerization and ultimately leads to cell death. Moreover, numerous reports highlight the cytotoxic effects ... more

Design and Synthesis of NO-releasing Betulinic Acid Derivatives as Potential Anticancer Agents

Abstract: A total of 16 targeted NO-releasing betulinic acid (BA) derivatives were designed and synthesized as potential anticancer agents. Most IC50 values were under 1.0 μM in vitro test against HepG2 and B16. The result suggested that derivatives of BA with α,β-unsaturated ketone skelet ... more

Synthetic Mono/di-halogenated Coumarin Derivatives and Their Anticancer Properties

Abstract: Background: Coumarins are naturally occurring plant metabolites and several synthetic coumarin analogues are known for their various pharmacological properties such as anticoagulant, antimicrobial, anticancer, antioxidant, anti-inflammatory and antiviral properties. Objective; K ... more

Differential Cytotoxicity, Cellular Uptake, Apoptosis and Inhibition of BRCA1 Expression of BRCA1-Defective and Sporadic Breast Cancer Cells Induced by an Anticancer Ruthenium( ...

Abstract: Background: The RAPTA-EA1 complex [ruthenium(II)-arene 1,3,5-triaza-7-phosphaadamantane (pta) complex with an arene-tethered ethacrynic acid ligand] has been reported to overcome drug resistance that developed due to the current use of platinum-based treatments. However, the exac ... more

All publications on pharma

A novel BCMA|[sol]|CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo Leukemia advance online publication, January 13 2017. doi:10.1038/leu.2016.388 Authors: S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Ratte ... more

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Leukemia advance online publication, January 3 2017. doi:10.1038/leu.2016.352 Authors: E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeyc ... more

Energy metabolism in the rat cortex under thiopental anaesthesia measured In Vivo by 13C MRS

Barbiturates, commonly used as general anaesthetics, depress neuronal activity and thus cerebral metabolism. Moreover, they are likely to disrupt the metabolic support of astrocytes to neurons, as well as the uptake of nutrients from circulation. By employing 13C magnetic resonance spectros ... more

The involvement of thrombin in the pathogenesis of glioblastoma

Abstract Prothrombin and its active derivative thrombin are key members of the coagulation system. The only site of extra‐hepatic thrombin expression is the central nervous system (CNS), where it is involved in brain development, protection, and regeneration. Thrombin affects various deg ... more

Chlamydia trachomatis and HPV co‐infections in HIV negative men from a multi‐ethnic area of Northern Italy at high prevalence of cervical malignancies

ABSTRACT Chlamydia trachomatis and HPV coinfections in the male population are often a disregarded issue. We performed a study to evaluate the prevalence of such infections in heterosexual HIV negative men from a Northern Italy multi‐ethnic area at high prevalence for cervical malignanc ... more

All publications on healthcare
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