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Publications

Search for science publications by its title or author and refine your search on the basis of publishing houses, year etc.

Current publications

A novel BCMA|[sol]|CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo Leukemia advance online publication, January 13 2017. doi:10.1038/leu.2016.388 Authors: S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Ratte ... more

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Leukemia advance online publication, January 3 2017. doi:10.1038/leu.2016.352 Authors: E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeyc ... more

Legal approaches regarding health-care decisions involving minors: implications for next-generation sequencing

Legal approaches regarding health-care decisions involving minors: implications for next-generation sequencing European Journal of Human Genetics 25, 658 (May 2017). doi:10.1038/ejhg.2017.41 Authors: Karine Sénécal, Kristof Thys, Danya F Vears, Kristof Van Assche, Bart ... more

Long-read ChIA-PET for base-pair-resolution mapping of haplotype-specific chromatin interactions

Nature Protocols 12, 899 (2017). doi:10.1038/nprot.2017.012 Authors: Xingwang Li, Oscar Junhong Luo, Ping Wang, Meizhen Zheng, Danjuan Wang, Emaly Piecuch, Jacqueline Jufen Zhu, Simon Zhongyuan Tian, Zhonghui Tang, Guoliang Li & Yijun Ruan Chromatin interaction analysis b ... more

Metabolic Profiling of asthma in mice and the interventional effects of SPA using Liquid Chromatography and Q-TOF Mass Spectrometry

Asthma is a chronic inflammatory lung disease lead to 250,000 deaths annually. It is need to better understand asthma by identifying new pathogenic molecules. We conducted a liquid-chromatography with time-of-flight mass spectrometer (LC-Q-TOF-MS)-based metabolomics study to intestate of as ... more

All publications

Legal approaches regarding health-care decisions involving minors: implications for next-generation sequencing

Legal approaches regarding health-care decisions involving minors: implications for next-generation sequencing European Journal of Human Genetics 25, 658 (May 2017). doi:10.1038/ejhg.2017.41 Authors: Karine Sénécal, Kristof Thys, Danya F Vears, Kristof Van Assche, Bart ... more

Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration

Publication date: Available online 12 April 2017 Source:Acta Biomaterialia Author(s): Alessandra Bari, Nora Bloise, Sonia Fiorilli, Giogia Novajra, Maria Vallet-Regí, Giovanna Bruni, Almudena Torres-Pardo, José M. González-Calbet, Livia Visai, Chiara Vitale- Brovar ... more

One-dimensional Poly(L-Lysine)-block-Poly(L-Threonine) Assemblies Exhibit Potent Anticancer Activity by Enhancing Membranolysis

Publication date: Available online 13 April 2017 Source:Acta Biomaterialia Author(s): Yu-Fon Chen, Ai-Li Shiau, Sue-Joan Chang, Nai-Shin Fan, Chung-Teng Wang, Chao-Liang Wu, Jeng-Shiung Jan Herein, we report the oncolytic activity of cationic, one-dimensional (1D) fibril ... more

Affinity interactions drive post-implantation drug filling, even in the presence of bacterial biofilm

Publication date: Available online 13 April 2017 Source:Acta Biomaterialia Author(s): Erika L. Cyphert, Sean T. Zuckerman, Horst A. von Recum, Julius N. Korley Current post-operative standard of care for surgical procedures, including device implantations, dictates prophylacti ... more

Native and solubilized decellularized extracellular matrix: a critical assessment of their potential for improving the expansion of mesenchymal stem cells

Publication date: Available online 12 April 2017 Source:Acta Biomaterialia Author(s): Aida Shakouri-Motlagh, Andrea J. O'Connor, Shaun P. Brennecke, Bill Kalionis, Daniel E. Heath Capturing the promise of mesenchymal stem cell (MSC)-based treatments is currently limited by i ... more

All publications on biotechnology

Issue Information

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Fetal left‐sided cardiac structural dimensions in left‐sided congenital diaphragmatic hernia ‐ association with severity and impact on postnatal outcomes

Abstract Objectives Fetuses with congenital diaphragmatic hernia (CDH) demonstrate varying degrees of left heart hypoplasia. Our study assesses the relationship between fetal left‐sided cardiac structural dimensions, lung size, percentage liver herniation, lung‐to‐head ratio, postnatal ... more

Clinical applications of 3D volume MR imaging of the fetal brain in utero

Abstract Objective In our earlier publication we described the methods of acquiring 3D volume MR data in second and third trimester fetuses and provided normative data from a large cohort of normal fetuses. In this paper we show the applicability of the technique by describing five fet ... more

Outcome of isolated enlarged cisterna magna identified in utero: experience at a single medical center in mainland China

Abstract Objective To explore the effects of prenatal isolated enlarged cisterna magna (IECM) on postnatal development. Methods We followed up 123 fetuses with an enlarged cisterna magna (ECM), who were divided into IECM (Group 1) and non‐IECM (ECM plus other anomalies, Group 2) ... more

The Benefits and Limitations of cell‐free DNA screening for 47, XXY (Klinefelter syndrome)

Abstract Objective The purpose of this paper is to provide an overview of the 47, XXY syndrome, which is the most commonly occurring X and Y chromosomal variation. This paper seeks to review what is currently known of noninvasive prenatal testing (NIPT) and 47, XXY, and investigate pot ... more

All publications on diagnostics

The evolving concept of cancer stem-like cells in thyroid cancer and other solid tumors

The evolving concept of cancer stem-like cells in thyroid cancer and other solid tumors Laboratory Investigation advance online publication, April 10 2017. doi:10.1038/labinvest.2017.41 Authors: Heather Hardin, Ranran Zhang, Holly Helein, Darya Buehler, Zhenying Guo & Ricardo ... more

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 97, 354 (April 2017). doi:10.1038/labinvest.2017.27 more

T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy

T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy Laboratory Investigation advance online publication, March 27 2017. doi:10.1038/labinvest.2017.25 Authors: Robert Sackstein, Tobias Schatton & Steven R Barthel more

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology Laboratory Investigation advance online publication, March 6 2017. doi:10.1038/labinvest.2017.9 Authors: Akinori Kawakami & David E Fisher more

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 97, 230 (March 2017). doi:10.1038/labinvest.2017.7 more

All publications on lab technology

Dapagliflozin-citric acid cocrystal showing better solid state properties than dapagliflozin

Publication date: Available online 13 April 2017 Source:European Journal of Pharmaceutical Sciences Author(s): Jun-Hui Deng, Tong-Bu Lu, Changquan Calvin Sun, Jia-Mei Chen Dapagliflozin (DAP) is a potent and selective sodium-glucose contransporter-2 inhibitor, for treating typ ... more

Effect of micro-environment modification and polymer type on the in-vitro dissolution behavior and in-vivo performance of amorphous solid dispersions

Publication date: Available online 13 April 2017 Source:European Journal of Pharmaceutical Sciences Author(s): Weiwei Sun, Baoliang Pan This study investigates the effects of micro-environment modification and polymer type on the in-vitro dissolution behavior and in-vivo performan ... more

Impact of demographics and disease progression on the relationship between glucose and HbA1c

Publication date: Available online 13 April 2017 Source:European Journal of Pharmaceutical Sciences Author(s): Anetta Claussen, Jonas B. Møller, Niels R. Kristensen, Søren Klim, Maria C. Kjellsson, Steen H. Ingwersen, Mats O. Karlsson Context Several studies have shown t ... more

Block ionomer micellar nanoparticles from double hydrophilic copolymers, classifications and promises for delivery of cancer chemotherapeutics

Publication date: Available online 14 April 2017 Source:European Journal of Pharmaceutical Sciences Author(s): S.S. Abolmaali, A.M. Tamaddon, M. Salmanpour, S. Mohammadi, R. Dinarvand A class of double hydrophilic copolymers comprising ionic and nonionic water-soluble blocks ... more

Innovative approach for identifying root causes of glass defects in sterile drug product manufacturing

Publication date: 15 June 2017 Source:European Journal of Pharmaceutical Sciences, Volume 104 Author(s): Lukas Eberle, Alexander Svensson, Andreas Graser, Joerg Luemkemann, Hirokazu Sugiyama, Rainer Schmidt, Konrad Hungerbuehler In sterile drug product manufacturing, scr ... more

All publications on pharma

A novel BCMA|[sol]|CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo Leukemia advance online publication, January 13 2017. doi:10.1038/leu.2016.388 Authors: S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Ratte ... more

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Leukemia advance online publication, January 3 2017. doi:10.1038/leu.2016.352 Authors: E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeyc ... more

Phenotypic expression of 19q13.32 microdeletions: Report of a new patient and review of the literature

The phenotypic manifestations of microdeletions in the 19q13.32 region are still poorly known. In this paper we report a patient who presented with hypotonia, developmental delay, facial dysmorphism, micrognathia, kyphoscoliosis, and buried penis. Chromosomal microarray revealed an intersti ... more

Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin–EGFR Pathway

Lung cancers with activating KRAS mutations are characterized by treatment resistance and poor prognosis. In particular, the basis for their resistance to radiation therapy is poorly understood. Here, we describe a radiation resistance phenotype conferred by a stem-like subpopulation charac ... more

eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth

In pancreatic ductal adenocarcinoma (PDAC), mutant KRAS stimulates the translation initiation factor eIF5A and upregulates the focal adhesion kinase PEAK1, which transmits integrin and growth factor signals mediated by the tumor microenvironment. Although eIF5A-PEAK1 signaling contributes t ... more

All publications on healthcare
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