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Publications

Search for science publications by its title or author and refine your search on the basis of publishing houses, year etc.

Current publications

Prp8 positioning of U5 snRNA is linked to 5' splice site recognition [REPORT]

Prp8 is an essential protein that regulates spliceosome assembly and conformation during pre-mRNA splicing. Recent cryo-EM structures of the spliceosome model Prp8 as a scaffold for the spliceosome's catalytic U snRNA components. Using a new amino acid probing strategy, we identified a dyna ... more

Development of mnemonic discrimination during childhood [BRIEF COMMUNICATIONS]

The present study examined mnemonic discrimination in 5- and 6-yr-old children, 8- and 9-yr-old children, 11- and 12-yr-old children, and young adults. Participants incidentally encoded pictorial stimuli and subsequently judged whether targets (i.e., repeated stimuli), lures (i.e., mnemonic ... more

EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response [ARTICLE]

Mutations in eIF2B genes cause vanishing white matter disease (VWMD), a fatal leukodystrophy that can manifest following physical trauma or illness, conditions that activate the integrated stress response (ISR). EIF2B is the guanine exchange factor for eIF2, facilitating ternary complex for ... more

A complex mTOR response in habituation paradigms for a social signal in adult songbirds [RESEARCH]

Nonassociative learning is considered simple because it depends on presentation of a single stimulus, but it likely reflects complex molecular signaling. To advance understanding of the molecular mechanisms of one form of nonassociative learning, habituation, for ethologically relevant sign ... more

MicroRNA duplication accelerates the recruitment of new targets during vertebrate evolution [ARTICLE]

The repertoire of miRNAs has considerably expanded during metazoan evolution, and duplication is an important mechanism for generating new functional miRNAs. However, relatively little is known about the functional divergence between paralogous miRNAs and the possible coevolution between du ... more

All publications

Prp8 positioning of U5 snRNA is linked to 5' splice site recognition [REPORT]

Prp8 is an essential protein that regulates spliceosome assembly and conformation during pre-mRNA splicing. Recent cryo-EM structures of the spliceosome model Prp8 as a scaffold for the spliceosome's catalytic U snRNA components. Using a new amino acid probing strategy, we identified a dyna ... more

EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response [ARTICLE]

Mutations in eIF2B genes cause vanishing white matter disease (VWMD), a fatal leukodystrophy that can manifest following physical trauma or illness, conditions that activate the integrated stress response (ISR). EIF2B is the guanine exchange factor for eIF2, facilitating ternary complex for ... more

MicroRNA duplication accelerates the recruitment of new targets during vertebrate evolution [ARTICLE]

The repertoire of miRNAs has considerably expanded during metazoan evolution, and duplication is an important mechanism for generating new functional miRNAs. However, relatively little is known about the functional divergence between paralogous miRNAs and the possible coevolution between du ... more

Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins [ARTICLE]

The four dengue viruses (DENV1-4) are rapidly reemerging infectious RNA viruses. These positive-strand viral genomes contain structured 3' untranslated regions (UTRs) that interact with various host RNA binding proteins (RBPs). These RBPs are functionally important in viral replication, pat ... more

HnRNP L represses cryptic exons [BIOINFORMATICS]

The fidelity of RNA splicing is regulated by a network of splicing enhancers and repressors, although the rules that govern this process are not yet fully understood. One mechanism that contributes to splicing fidelity is the repression of nonconserved cryptic exons by splicing factors that ... more

All publications on biotechnology

Clinical Experience of Laboratory Follow‐Up with Non‐Invasive Prenatal Testing Using Cell‐Free Dna and Positive Microdeletion Results in 349 Cases

Abstract Objective Screening via non‐invasive prenatal testing (NIPT) involving the analysis of cell‐free DNA (cfDNA) from plasma has become readily available to screen for chromosomal and DNA aberrations through maternal blood. This report reviews a laboratory's experience with follow ... more

Patient‐controlled tissue collection for genetic testing after early pregnancy loss, a pilot study

Abstract Objective To determine how frequently and effectively products of conception can be obtained among women pursuing medical management of early pregnancy loss. Methods This pilot study was conducted to assess products of conception recovery outcomes for participants optin ... more

Noninvasive reconstruction of placental methylome from maternal plasma DNA: potential for prenatal testing and monitoring

Abstract Objective During human pregnancy, the DNA methylation of placental tissue is highly relevant to the normal growth and development of the fetus, therefore methylomic analysis of the placental tissue possesses high research and clinical value in prenatal testing and monitoring. ... more

Myocardial Injury in Fetal Aortic Stenosis: Insights from Amniotic Fluid Analysis

Abstract Objective Fetal aortic stenosis (AS) imposes pressure load on the developing left ventricle (LV) and leads to derangements in myocardial structure and function via mechanisms that are not well characterized. Methods We compared amniotic fluid NT‐BNP and troponin levels ... more

Ultrasound findings provide clues to investigate founder mutations expressed as runs of homozygosity in chromosomal microarray studies

Abstract Objectives Chromosomal microarray (CMA) analysis is effectively applied prenatally to detect copy number changes. SNP probes included in the microarray platform can detect regions of excessive homozygosity (ROH) and identical‐by‐descent genomic stretches. The utility of the la ... more

All publications on diagnostics

Establishment of a nasopharyngeal carcinoma cell line capable of undergoing lytic Epstein–Barr virus reactivation

Epstein–Barr virus (EBV) infects more than 90% of the adult human population. Undifferentiated nasopharyngeal carcinoma (NPC) is common in Southeast Asia, with a particularly high incidence among southern Chinese. The EBV genome can be detected in practically all cancer cells in undifferent ... more

Mutation screening using formalin-fixed paraffin-embedded tissues: a stratified approach according to DNA quality

DNA samples from formalin-fixed paraffin-embedded tissues are highly degraded with variable quality, and this imposes a big challenge for targeted sequencing due to false positives, largely caused by PCR errors and cytosine deamination. To eliminate false positives, a common practice is to ... more

Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice

Enterovirus (EV) 71 infection has been widely acknowledged as the leading cause of severe hand, foot and mouth disease (HFMD), which may rapidly lead to fatal pulmonary edema. In this study, we established a mouse model for EV71 infection exhibiting high incidence of severe symptoms with pu ... more

Microvascular fractal dimension predicts prognosis and response to chemotherapy in glioblastoma: an automatic image analysis study

The microvascular profile has been included in the WHO glioma grading criteria. Nevertheless, microvessels in gliomas of the same WHO grade, e.g., WHO IV glioblastoma (GBM), exhibit heterogeneous and polymorphic morphology, whose possible clinical significance remains to be determined. In t ... more

Nanovesicle-mediated delivery of anticancer agents effectively induced cell death and regressed intrahepatic tumors in athymic mice

Hepatocellular carcinoma is highly resistant to chemotherapy. Here we evaluated the use and efficacy of milk-derived nanovesicles (MNV) as an approach to improve delivery of anticancer agents into HCC cells and intrahepatic tumors. We developed a protocol for isolation of MNVs from skim mil ... more

All publications on lab technology

Corneal and conjunctival drug permeability: Systematic comparison and pharmacokinetic impact in the eye

Publication date: 1 July 2018 Source:European Journal of Pharmaceutical Sciences, Volume 119 Author(s): Eva Ramsay, Eva M. del Amo, Elisa Toropainen, Unni Tengvall-Unadike, Veli-Pekka Ranta, Arto Urtti, Marika Ruponen On the surface of the eye, both the cornea and conjun ... more

Additive potential of combination therapy against cryptococcosis employing a novel amphotericin B and fluconazole loaded dual delivery system

Publication date: 1 July 2018 Source:European Journal of Pharmaceutical Sciences, Volume 119 Author(s): Azmat Ali Khan, Amer M. Alanazi, Mumtaz Jabeen, Shahanavaj Khan, Abdul Malik Cryptococcus neoformans is one of the most lethal fungi causing mortality across the globe. I ... more

Salt formation improved the properties of a candidate drug during early formulation development

Publication date: 30 July 2018 Source:European Journal of Pharmaceutical Sciences, Volume 120 Author(s): Kalle Sigfridsson, Matti Ahlqvist, Martin Lindsjö, Stefan Paulsson The purpose of this study was to investigate if AZD5329, a dual neurokinin NK1/2 receptor antagonist, is ... more

Dose-reduction antiangiogenic curcumin-low molecular weight heparin nanodrugs for enhanced combinational antitumor therapy

Publication date: 1 July 2018 Source:European Journal of Pharmaceutical Sciences, Volume 119 Author(s): Yan Xiao, Cheng Xu, Hui Xiong, Shi Du, Jianping Zhou, Lifang Yin, Jing Yao Curcumin (CUR) is a natural diketone with diverse bioactivities of inhibiting angiogenesis a ... more

In situ quantitative bioanalysis of monomethyl auristatin E-conjugated antibody-drug conjugates by flow cytometry

Publication date: 30 July 2018 Source:European Journal of Pharmaceutical Sciences, Volume 120 Author(s): Wen-Bin Zhao, Chi-Xiao Qiu, Ying Shen, Wen-Hui Liu, Jie Zhou, Ying-Chun Xu, Zhan Zhou, Shu-Qing Chen Antibody-drug conjugates (ADCs) consist of cytotoxic agents cov ... more

All publications on pharma

NUDT21 negatively regulates PSMB2 and CXXC5 by alternative polyadenylation and contributes to hepatocellular carcinoma suppression

Alternative polyadenylation (APA) is an important post-transcriptional regulatory mechanism and involved in many diseases, including cancer. CFIm25, a subunit of the cleavage factor I encoded by NUDT21, is required for 3′RNA cleavage and polyadenylation. Although it has been recently report ... more

Author Correction: Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel

Author Correction: Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel Author Correction: Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel, Publi ... more

E-cadherin in contact inhibition and cancer

E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin ... more

Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer

CDK8 is a transcription-regulating kinase that controls TGF-β/BMP-responsive SMAD transcriptional activation and turnover through YAP1 recruitment. However, how the CDK8/YAP1 pathway influences SMAD1 response in cancer remains unclear. Here we report that SMAD1-driven epithelial-to-mesenchy ... more

Author Correction: The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients

Author Correction: The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients Author Correction: The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients, Published o ... more

All publications on healthcare
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