Protein Kinases

Companies Protein Kinases

News Protein Kinases

• Heptares provides Gpcr expertise to new European drug discovery consortium

  Heptares Therapeutics is joining a group of European academic and industry researchers known as the ‘K4DD’ (‘Kinetics for Drug Discovery’) Consortium to investigate binding kinetics or ‘kinotypic’ properties of drug-receptor complexes. The five-year program will focus on important drug target classe more

• Astex Announces Commencement of Phase I Study for AZD5363 in Anti-Cancer Collaboration with AstraZeneca

  Astex Therapeutics confirmed the commencement of a Phase I study for AZD5363, a Protein Kinase B (PKB, also known as Akt) inhibitor. AZD5363 is a clinical candidate selected in January 2010 by AstraZeneca subsequent to its collaborative programme with Astex.  The collaborative programme originated f more

• MIT biologists find that restoring the gene for cancer protein p53 slows spread of advanced tumors

  In a new study published in Nature, MIT cancer biologists show that restoring the protein p53's function in mice with lung cancer has no effect early in tumor development, but restoring the function later on could prevent more advanced tumors from spreading throughout the body. Cancer researchers more

White papers Protein Kinases

• Epitope Mapping Using the In Vitro Rapid Translation System RTS 100
  

  The Rapid Translation System (RTS) represents a cell-free system that allows efficient production of protein from linear DNA sequences. This article gives a brief outline of the use of the RTS technology in linear epitope mapping and shows its promise for reducing time-consuming cloning and cell-lysis steps. more

• qPCR Validation of Candidates for Modulators of the MAPkinase Signaling Pathway
  

  With the completion of the human genome sequence, the detailed understanding of gene functions by analyzing the structure, biological activities, and dynamics of the encoded proteins has become the next challenge. The technology of RNA interference (RNAi), which allows the silencing of genes by introduction of small interfering RNA (siRNA), is recognized as an extremely powerful tool for systematic high-throughput functional genomic screening. more

• RealTime ready - Function Tested qPCR Assays Based on the Universal ProbeLibrary Technology
  

  RealTime ready qPCR Assays redefine real-time qPCR because each assay is function-tested in PCR and qualified under strict criteria to assure superior performance. The RealTime ready Assays are based on the well-known Universal ProbeLibrary (UPL) technology and are available in a ready-to-use formulation as dried-down assays in LightCycler® 480 Multiwell Plates 96 and 384, or as a primer probe mix for single assays in a liquid formulation for all real-time PCR platforms available in the market more

Publications Protein Kinases

• Interspecific Divergence of Transcription Networks along Lines of Genetic Variance in Drosophila: Dimensionality, Evolvability, and Constraint

  Change in gene expression is a major facilitator of phenotypic evolution. Understanding the evolutionary potential of gene expression requires taking into account complex systems of regulatory networks, the structure of which could potentially bias evolutionary trajectories. We analyzed the evoluti more

• Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation

  Mutations in PKD1 (85%) or PKD2 (15%) account for almost all cases of autosomal dominant polycystic kidney disease (ADPKD). The ADPKD proteins, termed as polycystin-1 (PC1) and polycystin-2 (PC2), interact via their C-termini to form a receptor–ion channel complex whose function and regulation are more

• Towards an efficient approach to identify molecular scaffolds possessing selective or promiscuous compounds

  Abstract The concept of a recurrent scaffold present in a series of structures is common in medicinal drug discovery. We present a scaffold analysis of compounds screened across 100 sequence‐unrelated proteins to identify scaffolds that drive promiscuity or selectivity. Selectivity and promiscui more

Market studies Protein Kinases

• Novel Therapies in Oncology - Protein Kinase Inhibitors, Monoclonal Antibodies and Vaccines Therapeutic Classes Dominate Late-Stage Pipeline

  GBI Research, the leading business intelligence provider, has released its latest research, “Novel Therapies in Oncology - Protein Kinase Inhibitors, Monoclonal Antibodies and Vaccines Therapeutic Classes Dominate Late-Stage Pipeline” which provides insights into the global oncology pipeline. The re more

• Carna Biosciences, Inc. (4572) - Financial and Strategic SWOT Analysis Review

  Carna Biosciences, Inc. (Carna Biosciences) is a biotechnology company, principally engaged in the discovery and development of new drug candidates for the treatment of patients with cancer and anti-inflammatory diseases using QuickScout, an innovative kinase drug discovery platform. The company's p more

• Galapagos NV (GLPGA) - Financial and Strategic SWOT Analysis Review

  Galapagos NV (Galapagos) is a publicly held research focused biopharmaceutical company. It is engaged in discovery and development of disease modifying drugs. The company develops GLPG0259 that targets protein kinase MAPKAPK5, as its leading drug candidate for the under initial stages of clinical tr more

Websites Protein Kinases