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The limited efficacy and negative side-effects associated with current therapeutics for Hepatitis B and C are highlighting the urgent need for new, improved alternatives. Combination therapies offering better clinical outcomes are coming to the fore and look set to transform the European market for more
Medivir AB announced plans for a phase II proof-of-concept study of an all-oral regimen for the treatment of hepatitis C containing of Medivir/Janssen’s protease inhibitor simeprevir and Vertex’s nucleotide analogue hepatitis C virus (HCV) polymerase inhibitor VX-135. Janssen will conduct a drug-dru more
Medivir AB announced that its development partner, Tibotec Pharmaceuticals, has entered into an agreement with Bristol-Myers Squibb Company. TMC435, a once daily NS3/4A protease inhibitor (PI) for the treatment of genotype-1 chronic hepatitis C virus (HCV) infection will be investigated in combinat more
The cortical collecting duct regulates ion and water homeostasis in the kidney. A cell line denoted M-1 has been established from the cortical collecting duct of a transgenic mouse that exhibits many functional properties of the original tissue. While this cell line is valuable for in vitro studies, the cells are not easily transfected. Frequently, adenovirus-mediated gene transfer is used. As adenovirus production requires several additional steps, we prefer chemical methods to achieve recombinant protein expression in M-1 cells. Previous attempts to transfect this cell line were unsuccessful with far less than 10% of transfectants, although different reagents were tried. Here we compare three commercially available transfection reagents in terms of the percentage of transfected cells and the suitability for using a reporter construct in M-1 cells. more
Neuroblastoma cell lines can be models for the responsiveness of neuroblastomas to chemotherapy-induced cell death as well as for the sensitivity of untransformed neuro-nal cells to toxic side-effects of chemotherapy. Both phenom-ena are relevant to neuroblastoma cells exposed to bortezomib, a proteasome inhibitor in clinical use. It has been shown previously that neuroblastoma cell lines are prone to undergo apoptosis when treated with bortezomib, but the precise molecular mechanism has not been revealed. In addition to this, peripheral neuropathy is the main side effect of chemotherapy that includes bortezomib more
Two siblings from consanguineous parents died perinatally with a condition characterized by generalized hypotonia, respiratory insufficiency, arthrogryposis, microcephaly, congenital brain malformations and hyperglycinemia. Catalytic activities of the mitochondrial respiratory complexes I and II we more
The Kunitz-type protease inhibitors are the best-characterized family of serine protease inhibitors, probably due to their abundance in several organisms. These inhibitors consist of a chain of ~60 amino acid residues stabilized by three disulfide bridges, and was first observed in the bovine pancre more
Despite the progress made in the early detection and treatment of prostate adenocarcinoma, the metastatic lesions from this tumor are incurable. We used genome-wide expression analysis of human prostate cancer cells with different metastatic behavior in animal models to reveal that bone-tropic pheno more
Introduction GlobalData, the industry analysis specialist, has released its new report, “Hepatitis B Therapeutics - Pipeline Assessment and Market Forecasts to 2019”. The report is an essential source of information and analysis on the global hepatitis B therapeutics market. The report identifies more
InterMune, Inc. (ITMN) - Financial and Strategic SWOT Analysis Review Summary InterMune, Inc. (InterMune) is a biopharmaceutical company engaged in the development and marketing of innovative therapies in areas of pulmonology and hepatology. The company is developing a pipeline of pulmonology and more
Introduction GlobalData has released its new report, “HIV-AIDS Therapeutics - Pipeline Assessment and Market Forecasts to 2017”. The report is an essential source of information and analysis on the global HIV/AIDS market. The report identifies the key trends shaping and driving the global HIV-AIDS more
Tools for Genomic Research . PRODUCT Tools for Genomic Research - full pdf ● Restriction Enzymes Introduction List of Isozymes List of Restriction Enzymes Reaction Buffer Diluent Buffer UniSol RE Buffer ● Modifying Enzymes T4 DNA Ligase T4 Polynucleotide Kinase DNA Polymerase I Klenow Fragment more
The Company at a Glance Related Links Achillion Corporate Fact Sheet download A complete listing of publications, presentations, and posters related to Achillion's product candidates can be found here Achillion is an innovative biopharmaceutical company dedicated to bringing important new treatmen more
Wersja polska Services Products About us News & events Contact Proteins Enzymes Inhibitors Recombinant proteins Proteins and peptides Clean Cut technology General terms and conditions Staphopain B: cysteine protease from S. aureus To order this product please send e-mail to: This e-mail address is more
Protease inhibitor pharmacology :For natural protease inhibitors, please see protease inhibitor (biology) Protease inhibitors (PIs) are a class of medication used to treat or prevent infection by virus es, including HIV and Hepatitis C . P ... more
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