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Accurate, efficient and flexible sample preparation with the HAMILTON MICROLAB® 600 Series

The MICROLAB 600® is a high-precision syringe pump with a graphical user interface designed to quickly dilute and dispense liquids more

News pressure

• Bayer focuses resources on growth and innovation

  Bayer plans to invest its resources even more systematically in growing the company and enhancing its innovative capability. The focus will be on researching, developing and marketing new products, particularly in HealthCare and CropScience, and on expanding activities in the emerging markets. This more

• Manufacturing Safety Raises Concern

  Last week Pharmaceutical heads met as a result of a drugs recall after a pill mix up of breast cancer pills. The drug, Fresenius Kabi’s Anastrozole, was made by the German company’s subsidiary in India. The ingredient mix up led to the voluntary recall of 7,192 bottles, each containing 30 tablets. more

• Radio chip and sensor in one

  RFID technology is on the advance. But, up to now radio chips primarily supply data for the identification of products. Researchers have now developed a transponder which measures temperature, pressure and humidity. The chip with sensor function could revolutionize the applications market. »Special more

White papers pressure

• CO2 Gas Calibration with eVol®, the digital analytical syringe
  

  Using eVol® for injection of different volumes of CO2, CEP/TEP was able to achieve calibration of their instrument with levels of accuracy and precision not previously obtained using manual syringes. In addition, the needles on the eVol® syringes allow for sample collection directly from the gas bottle – similarly to the manual syringes used previously more

• Increased productivity for downstream processing of biotherapeutics
  

  Polymer-based chromatographic resins featuring high mechanical and chemical stability and high protein binding capacities can help to increase the throughput and robustness of biopharmaceutical manufacturing processes. Advances in genetic engineering and cell culture technology have raised upstream productivity in the production of recombinant proteins. Increased titres of up to 10 g/l stress the need for highly efficient and robust downstream processes (DSP). Most industrial bioprocess development groups apply generic DSP platforms that are designed to purify various candidates of the same class of proteins applying the same process design. Besides various filtration and virus inactivation steps, they usually involve two or three chromatographic unit operations with orthogonal separation modes. The use of high capacity chromatographic resins can help to overcome the DSP bottleneck by increasing process throughput and robustness more

• Increased Vitality of Primary Mouse Hepatocytes Isolated with Liberase TM Research Grade
  

  As drugs applied to organisms are metabolized via the liver, hepatocytes represent a useful and common study model. Primary hepatocytes are widely used to evaluate the toxic effects of drugs and xenobiotics. A variety of metabolic parameters have been described to analyze the functionality of hepatocytes. Via those parameters, the toxic effect of substances can easily be quantified. One drawback of primary hepatocyte culture is the short duration of survival and the high sensibility of the cells. Therefore, every step towards a more gentle method of isolating the cells increases cell number and vitality and thus improves the outcome of biomedical research applications more

Publications pressure

• Involvement of the L‐arginine/nitric oxide/cyclic guanosine monophosphate pathway in peripheral antinociception induced by N‐palmitoyl‐ethanolamine in rats

  Abstract N‐palmitoyl‐ethanolamine (PEA) is an endogenous substance that was first identified in lipid tissue extracts. It has been classified as a CB2 receptor agonist. Exogenous PEA has the potential to become a valid treatment for neuropathic and inflammatory pain. In spite of the well‐demonstr more

• Increased aquaporin‐1 and Na+‐K+‐2Cl– cotransporter 1 expression in choroid plexus leads to blood–cerebrospinal fluid barrier disruption and necrosis of hippocampal CA1 cells i ...

  Abstract Hyponatremia is a metabolic disorder characterized by increased cerebrospinal fluid (CSF) volume and pressure, although the site of brain insult is unclear. Specifically, the hippocampus, which is in direct contact with expanding CSF ventricles, may be involved. The present study was und more

• Measurements of elastic moduli of pharmaceutical compacts: A new methodology using double compaction on a compaction simulator

  Abstract The elastic properties of pharmaceutical powders play an important role during the compaction process. The elastic behavior can be represented by Young's modulus (E) and Poisson's ratio (v). However, during the compaction, the density of the powder bed changes and the moduli must be dete more

Market studies pressure

• Turkey Pharmaceuticals and Healthcare Report Q2 2012

  BMI View: While the Turkish pharmaceutical industry has achieved some concessions following additional price cuts and public discounts announced in November 2011, the impact of the November decree remains negative. That aside, BMI emphasises that the number-one concern for drugmakers in 2012 should more

• Europe Wound Care Management Market Outlook to 2017- Advanced Wound Management, Wound Closure Devices, Pressure Relief Devices and Others

  Introduction GlobalData’s new report, “Europe Wound Care Management Market Outlook to 2017- Advanced Wound Management, Wound Closure Devices, Pressure Relief Devices and Others” provides key market data on the Europe Wound Care Management market – France, Germany, Italy, Spain and United Kingdom. more

• Sweden Wound Care Management Market Outlook to 2017 - Advanced Wound Management, Wound Closure Devices, Pressure Relief Devices and Others

  Introduction GlobalData’s new report, “Sweden Wound Care Management Market Outlook to 2017 - Advanced Wound Management, Wound Closure Devices, Pressure Relief Devices and Others” provides key market data on the Sweden Wound Care Management market. The report provides value (USD million), volume (un more

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