Oxidative Stress

News Oxidative Stress

• Mild blast injury causes molecular changes in brain akin to Alzheimer

  A multicenter study led by scientists at the University of Pittsburgh School of Medicine shows that mild traumatic brain injury after blast exposure produces inflammation, oxidative stress and gene activation patterns akin to disorders of memory processing such as Alzheimer's disease. Their findings more

• Cold-blooded research has hearts thumping
  

  The protective effect of inducing controlled hypothermia following sudden cardiac arrest will now be investigated in detail. The goal of the scientific work is to judge whether this type of cryotherapy can be improved when using parallel simultaneous invasive resuscitation procedures. Establishing a more

• Oxidative stress and altered gene expression occurs in a metabolic liver disease model

  A team of researchers under the direction of Dr. Jeffrey Teckman in the Department of Pediatrics at St. Louis University, have demonstrated that oxidative stress occurs in a genetic model of alpha-1-antitrypsin deficiency. This is the most common genetic liver disorder in children and can lead to ci more

White papers Oxidative Stress

• ORAC Assay Performed on the POLARstar Omega and PHERAstar FS microplate reader
  

  In all oxygen consuming cells, metabolism and oxidative stress generate several intermediates and byproducts that are collectively known as reactive oxygen species (ROS). ROS are necessary intermediates in the human body, but they are also involved in the aging process and in the development of many degenerative diseases, including cancer, heart disease, Alzheimer's and Parkinson's. Herein we describe the determination of the antioxidant capacity of different fruit juices using the ORAC assay; a standardized method that uses Trolox®, a water-soluble analogue of vitamin E, as a standard substance more

• Detection of NADH and NADPH with the Omega's High Speed, Full UV/Vis Absorbance Spectrometer
  

  Nicotinamide Adenine Dinucleotide (NAD+), reduced nicotinamide adenine dinucleotide (NADH), nicotinamide adenine dinucleotide phosphate (NADP+) and reduced nicotinamide adenine dinucleotide phosphate (NADPH) have been known to play vital roles in energy metabolism, antioxidation, and reductive biosynthesis. In recent years, these co-factors have been shown to be involved in other physiological functions as well, including aging, oxidative stress, intracellular calcium homeostasis, ROS production, cell death and gene expression. more

Publications Oxidative Stress

• The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum–mitochondria tet ...

  DJ-1 was first identified as an oncogene. More recently, mutations in its gene have been found causative for autosomal recessive familial Parkinson disease. Numerous studies support the DJ-1 role in the protection against oxidative stress and maintenance of mitochondria structure; however, the mech more

• Shared Effects of Genetic and Intrauterine and Perinatal Environment on the Development of Metabolic Syndrome

  by Patricia M. Vuguin, Kirsten Hartil, Michael Kruse, Harpreet Kaur, Chia-Lei Vivian Lin, Ariana Fiallo, Alan Scott Glenn, Avanee Patel, Lyda Williams, Yoshinori Seki, Ellen B. Katz, Maureen J. Charron Genetic and environmental factors, including the in utero environment, contribute to Metabolic more

• Superoxide poisons mononuclear iron enzymes by causing mismetallation

  Summary Superoxide (O2‐) is a primary agent of intracellular oxidative stress. Genetic studies in many organisms have confirmed that excess O2‐ disrupts metabolism, but to date only a small family of [4Fe‐4S] dehydratases have been identified as direct targets. This investigation reveals that in more

Market studies Oxidative Stress

• LifeVantage Corporation (LFVN) - Financial and Strategic SWOT Analysis Review

  LifeVantage Corporation (LifeVantage) is a publicly traded company engaged in the manufacture, marketing and distribution of its dietary supplements and products. It also offers anti-aging and wellness products. The product portfolio of the company include Protandim, which is a supplement used to re more

• Oxford Biomedical Research, Inc. - Strategic SWOT Analysis Review

  Oxford Biomedical Research, Inc. (OBR) is engaged in the development and manufacture of immunoassay products, such as ELISA kits for the quantification of bioactive lipids in cells and biological fluids. It manufactures and distributes biological reagents, assay kits and services. The company lays p more

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