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514 Current news about the topic alzheimer's disease

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Artificial intelligence identifies anti-aging drug candidates targeting ‘zombie’ cells

New platform has potential to fuel advances in senolytic anti-aging compounds and longevity research

09-May-2023 - Anew publicationin the May issue ofNature Agingby researchers from Integrated Biosciences, a biotechnology start-up company combining synthetic biology and machine learning to target aging, demonstrates the power of artificial intelligence (AI) to discover novel senolytic compounds, a class ...

ageing Alzheimer's disease artificial intelligence +12
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Newfound link between Alzheimer’s and iron could lead to new medical interventions

What if amyloid beta plaques aren’t the main cause of Alzheimer’s disease?

24-Apr-2023 - There is a growing body of evidence that iron in the brain may play a role in Alzheimer’s disease. Lending weight to that idea, a new imaging probe has for the first time shown that in the same regions of the brain where the amyloid beta plaques associated with Alzheimer’s occur, there is also an ...

Alzheimer's disease beta-Amyloid plaques ferroptosis +2
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Genetic heritage from the Stone Age influences our chance to have a long life

"Variations in the APOE gene have the highest genetic contribution to longevity"

14-Apr-2023 - Researchers at Kiel University have studied the evolutionary history of the longevity gene APOE. To do this, they analysed data obtained from human skeletons that are up to 12,000 years old. Our lifestyle has a very big influence on our life expectancy, such as our level of fitness, or whether we ...

Alzheimer's disease gene variants genes +3
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New insights into the development of Alzheimer's disease

Researchers investigate the influence of oxidative stress on peptide aggregation

07-Mar-2023 - Despite considerable advances in research, there is still no cure for many age-related diseases, such as Alzheimer’s. One hypothesis for the development of Alzheimer’s is the aggregation of peptides, i.e. their “clumping”, in the brains of people with the disease. But stress has also been ...

aggregation Alzheimer's disease cell membranes +2
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Degrading modified proteins could treat Alzheimer’s, other ‘undruggable’ diseases

New technique specifically targets and breaks apart certain proteins — rather than just interfering with them

03-Mar-2023 - Certain diseases, including Alzheimer’s, are currently considered “undruggable” because traditional small molecule drugs can’t interfere with the proteins responsible for the illnesses. But a new technique that specifically targets and breaks apart certain proteins — rather than just interfering ...

Alzheimer's disease protein degradation proteins
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Decoding cellular zipcodes

Researchers suspect that neurodegenerative diseases occur when messenger RNA goes astray in the neuron

02-Feb-2023 - With a new method, Marina Chekulaeva is able to identify “zipcodes” that assign a destination to mRNAs. She has now presented her method in the journal Nature Neuroscience. In neurodegenerative diseases, the loss of neurons leads to a variety of malfunctions. In Alzheimer’s disease, for example, ...

Alzheimer's disease amyotrophic lateral sclerosis brain +3
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Six minutes of high-intensity exercise could delay the onset of Alzheimer’s disease

How increasing a specific protein can protect the brain from cognitive decline

13-Jan-2023 - Six minutes of high-intensity exercise could extend the lifespan of a healthy brain and delay the onset of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. New research published in The Journal of Physiology shows that a short but intense bout of cycling increases ...

Alzheimer's disease brain neurodegenerative diseases +3
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How old is your brain, really?

AI-powered analysis accurately reflects risk of cognitive decline and Alzheimer’s disease based on brain age

11-Jan-2023 - The human brain holds many clues about a person’s long-term health — in fact, research shows that a person’s brain age is a more useful and accurate predictor of health risks and future disease than their birthdate. Now, a new artificial intelligence (AI) model that analyzes magnetic resonance ...

Alzheimer's disease artificial intelligence brain +3
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Can the AI driving ChatGPT help to detect early signs of Alzheimer's disease?

Drexel researchers use the chatbot to spot Alzheimer's indicators in spontaneous speech

03-Jan-2023 - The artificial intelligence algorithms behind the chatbot program ChatGPT — which has drawn attention for its ability to generate humanlike written responses to some of the most creative queries — might one day be able to help doctors detect Alzheimer’s Disease in its early stages. Research from ...

Alzheimer's disease artificial intelligence deep learning +1
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Why a healthy lifestyle is not enough to prevent dementia

Social disadvantage is associated with higher dementia risk

19-Dec-2022 - Dementia is on the rise in Germany. In the absence of treatment options, the focus is shifting to preventing dementia. In particular, a healthy lifestyle is considered beneficial for brain health. A study by the Faculty of Medicine now shows that opportunities for a healthy lifestyle are ...

Alzheimer's disease brain dementia +1