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Key factor in mitochondrial calcium uptake and bioenergetics identified

17-May-2016

Mitochondria are the energy-generating batteries of cells, but they also perform other critical functions, including protecting cells against calcium overload, a significant cause of cell death in certain cardiovascular and neurodegenerative diseases. Underlying this safety mechanism is a protein ...

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Small molecule inhibitor shows promise in precision cancer targeting

09-Nov-2015

Cancer cells with mutations in BRCA1 or BRCA2 genes, which serve a vital role in preserving the integrity of the genetic code, are key targets for cancer therapeutics. Yet, few agents can selectively eliminate cells deficient in BRCA, and none can do so without the risk of inducing drug ...

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Blinded by genetic mutation

Team characterizes genetic mutations linked to a form of blindness

05-Oct-2015

Achromatopsia is a rare, inherited vision disorder that affects the eye's cone cells, resulting in problems with daytime vision, clarity and color perception. It often strikes people early in life, and currently there is no cure for the condition. One of the most promising avenues for developing ...

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Temple University researchers eliminate the HIV virus from cultured human cells for first time

31-Jul-2014

The HIV-1 virus has proved to be tenacious, inserting its genome permanently into its victims' DNA, forcing patients to take a lifelong drug regimen to control the virus and prevent a fresh attack. Now, a team of Temple University School of Medicine researchers has designed a way to snip out the ...

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Temple scientists target DNA repair to eradicate leukemia stem cells

12-Dec-2012

Despite treatment with imatinib, a drug that targets chronic myeloid leukemia (CML, some patients may continue to be at risk for relapse because a tiny pool of stem cells is resistant to treatment and may even accumulate additional genetic aberrations, eventually leading to disease progression ...

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GVK Biosciences announces multi-year drug discovery collaboration with the Moulder Center for Drug Discovery Research, Temple University

30-Nov-2011

GVK Biosciences announced today that it has entered into a drug discovery alliance with the Moulder Center for Drug Discovery Research at Temple University. As part of the multi-year integrated drug discovery collaboration, GVK BIO will be responsible for the target validation, lead ...

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Marijuana component could ease pain from chemotherapy drugs

10-Oct-2011

A chemical component of the marijuana plant could prevent the onset of pain associated with drugs used in chemo therapy, particularly in breast cancer patients, according to researchers at Temple University's School of Pharmacy.The researchers published their findings, "Cannabidiol Prevents the ...

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