Cause and possible relief of cancer bone pain found

08-Jun-2017 - Saint Louis University researcher Daniela Salvemini, Ph.D., reports discovering a key molecular pathway that drives cancer-related bone pain while providing a potential solution with a drug that already is on the market. Salvemini, who is a professor of pharmacology and physiology at SLU, studies ...

Stopping Zika

University to launch human vaccine trial

27-Jun-2016 - Saint Louis University's vaccine center has been tapped by the National Institutes of Health to conduct a human clinical trial of a vaccine to prevent the Zika virus, which can cause devastating birth defects in babies. The study, which will not start for several months, will be conducted at ...

In lab research, scientists limit autistic behavior

07-Dec-2015 - In a study Saint Louis University researchers report that treating mice with a compound, SR1078, reduces autistic behavior. The drug, developed by Thomas Burris, Ph.D., chair of pharmacology and physiology at SLU, and his lab, increases the expression of genes that are known to be low in the ...

Oxidative stress and altered gene expression occurs in a metabolic liver disease model

02-Nov-2012 - A team of researchers under the direction of Dr. Jeffrey Teckman in the Department of Pediatrics at St. Louis University, have demonstrated that oxidative stress occurs in a genetic model of alpha-1-antitrypsin deficiency. This is the most common genetic liver disorder in children and can lead to ...

Saint Louis University investigators perfect new version of blood-regulator thrombin

Research harnesses enzyme's anti-blood clotting abilities

22-Jun-2010 - In research led by Enrico Di Cera, M.D., chair of the department of biochemistry and molecular biology at Saint Louis University School of Medicine, molecular biologists have discovered a way to harness the enzyme thrombin's anti-blood clotting properties. The finding opens the door to new ...

Protein from tick saliva studied for potential myasthenia gravis treatment

27-Mar-2009 - Looking for a better treatment for the autoimmune disease myasthenia gravis, researchers have found that a protein in tick saliva shows promise in limiting the severity of the disease in an animal model in a study published in the Annals of Neurology . "This disease can leave patients weak and ...

Research identifies type of vaccine that holds promise in protecting against TB

21-Oct-2008 - Researchers are one step closer to finding a vaccine that better protects against tuberculosis. An investigational vaccine for TB tested at Saint Louis University appears likely to offer significantly better protection against the potentially fatal disease than the one in current use. "Not only ...