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25 Current news of Ruhr-Universität Bochumrss
Inflammatory reactions should be taken under consideration in drug selection
Physicians at the Ruhr-Universität Bochum (RUB) have been investigating if established anti-epilepsy drugs have anti-inflammatory or pro-inflammatory properties – an effect for which these pharmaceutical agents are not usually tested. One of the substances tested caused stronger ...
The Michael J. Fox Foundation supports new project at the RUB
Cell biologists at the Ruhr-Universität Bochum (RUB) have launched a new project to unravel the role of the enzyme Parkin in promoting neuronal survival. The team of Prof Dr Konstanze F. Winklhofer from the Institute of Physiological Chemistry, Department of Molecular Cell Biology, is looking ...
Two opposing mechanisms regulate the transport of proteins in peroxisomes
Recycling or “scrap press”: physicians at the Ruhr-Universität have found out which molecular mechanisms decide about the fate of the import receptor Pex18. Pex18 is responsible for the import of proteins into specific cell components, namely peroxisomes. Two opposing regulatory circuits ...
Research team analyses genetic make-up of two pregnant females
Scientists have successfully analysed the genetic make-up of the offspring of pregnant coelacanth females for the first time. They found that the likelihood that the offspring is fathered by one single individual is very high – unlike with many other fish species. Analysis of the ...
How switch proteins are extracted from the membrane
Researchers from the Ruhr-Universität Bochum (RUB) and from the MPI Dortmund have for the first time successfully reproduced the recycling process of proteins regulating cellular transport in a biophysical experiment. In doing so, they traced in detail the way the central switch protein Rab ...
Mineralocorticoid receptors ensure flexible engagement of learning strategies
Whenever we have to acquire new knowledge under stress, the brain deploys unconscious rather than conscious learning processes. Neuroscientists at the Ruhr-Universität Bochum have discovered that this switch from conscious to unconscious learning systems is triggered by the intact function of ...
Composition of splicing complex in chloroplasts identified for the first time
To convert a gene into a protein, a cell first crafts a blueprint out of RNA. One of the main players in this process has been identified by researchers led by Dr. Jessica Jacobs at the Ruhr-Universität Bochum. The team “fished” a large complex of proteins and RNA, which is involved in the ...
Protein spheres in the nucleus give wrong signal for cell division
A new hypothesis has been developed by researchers in Bochum on how Alzheimer’s disease could occur. They analysed the interaction of the proteins FE65 and BLM that regulate cell division. In the cell culture model, they discovered spherical structures in the nucleus that contained FE65 and ...
Large defects will heal more quickly
For many patients the removal of several centimetres of bone from the lower leg following a serious injury or a tumour extraction is only the beginning of a long-lasting ordeal. Autologous stem cells have been found to accelerate and boost the healing process. Surgeons at the RUB clinic ...
Dysfunction in cerebellar Calcium channel causes motor disorders and epilepsy
A dysfunction of a certain Calcium channel, the so called P/Q-type channel, in neurons of the cerebellum is sufficient to cause different motor diseases as well as a special type of epilepsy. This is reported by the research team of Dr. Melanie Mark and Prof. Dr. Stefan Herlitze from the ...