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Haplobank – a biobank of reversible mutant embryonic stem cells

29-Sep-2017

The Penninger lab at the IMBA developed a biobank of revertible, mutant embryonic stem cells. This cell bank – called Haplobank - contains over 100,000 mutated, conditional mouse embryonic stem cell lines, targeting about 70% of the protein-coding genome. Genetic screens have revolutionized our ...

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Only lethal if sugar is present

Immunising cells against the biological weapon ricin

21-Sep-2017

The plant toxin ricin is one of the most poisonous naturally occurring proteins, making it an extremely dangerous bioweapon. Ricin attacks have made the headlines a number of times over the years, including the spectacular “umbrella murder” in London in the 1970s, or more recently the ricin ...

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Tuberculosis: Researchers Uncover how Bacteria Burst our Cells

11-Apr-2017

Scientists based in Vienna unveil the complex molecular structure that causes lethal infections by Mycobacterium tuberculosis (Mtb). Their findings might have implications for potential therapies against antibiotic-resistant tuberculosis. An international team of scientists across Europe, ...

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Unique genome architectures after fertilisation in single-cell embryos

30-Mar-2017

Using a newly developed method researchers at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) have been able to shed light on the complexity of genome reorganization occurring during the first hours after fertilization in the single-cell mammalian embryo. Using ...

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Scientists find a new way to protect against lethal fungal infections

20-Jul-2016

Scientists at the Institute of Molecular Biotechnology (IMBA) and the Max F. Perutz Laboratories (MFPL) in Vienna have discovered a new way to turn the immune system’s weapons against fungal invaders. This knowledge could lead to the development of new and improved anti-fungal treatments. For ...

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A protein coat helps chromosomes keep their distance

01-Jul-2016

Researchers at IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences have identified a protein that disperses chromosomes during cell division. Billions of your cells divide every day. Cell division fuels growth and also replaces short-lived cells in some organs, like ...

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Tremendous progress in the development of skin stem cell treatments for butterfly children

02-Dec-2014

Scientists at IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences in Vienna have made a major advancement towards a future therapy for butterfly children. A treatment with fibroblasts generated from induced pluripotent stem cells has been highly successful in mice. The ...

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This year’s research prize awarded by Eppendorf goes to Austria

Presentation of the 2014 Eppendorf Award for Young European Investigator to Madeline Lancaster

28-May-2014

The American scientist Madeline Lancaster, Ph. D. (Marie Curie Postdoctoral Research Fellow, Laboratory of Jürgen Knoblich at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences, IMBA, Vienna, Austria) has won the 2014 Eppendorf Award for Young European ...

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How malnutrition leads to inflamed intestines

27-Jul-2012

Researchers at the Institute of Molecular Biotechnology in Vienna, Austria, have uncovered how malnutrition, affecting millions of people, leads to diarrhoea, inflamed intestines and immune system disorders. This surprising result explains food effects that have been known for centuries and ...

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Zooming in on the Weapons of Salmonella

08-Mar-2011

Bacteria like salmonellae infect their host cells by needle-shaped extensions which they create in large numbers during an attack. A group of Vienna-based scientists headed by Thomas Marlovits employed recently developed methods of cryo-electron microscopy and have been able to clarify the ...

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