01-12-2010: Plasticell has announced the signing of a collaboration agreement with Sigma-Aldrich, a leading provider of technologies and reagents to the life science research market.
In the collaboration, Sigma-Aldrich will use its CompoZr® Zinc Finger Nuclease Technology to engineer various human stem cell lines that enable tracking of differentiation to specific mature cell types via fluorescent reporters, integrated directly into developmentally expressed genes. The technology enables highly efficient, precisely targeted knock-in of reporters, resulting in more reliable reporter systems than conventional transgenic methods which integrate reporters randomly throughout the genome. Plasticell will then use these cell lines in its CombiCult™ high throughput screening (HTS) system to develop novel stem cell differentiation protocols.
Under the Agreement, Plasticell will own resulting protocols for high efficiency, directed differentiation of stem cells, with Sigma-Aldrich marketing the reporter stem cell lines. Cells and media may be commercialised together in kits, while reporter cell lines can be linked to specific CombiCult™ screens, for optimised differentiation of human embryonic stem cells (ESC) or induced pluripotent cells (iPSC).
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The global leader in Life Science and High Technology research products, backed by extensive technical information and service support, we supply over 85,000 biochemicals and organic chemicals to the scientific community. For over 50 years, we've used our unrivaled scientific knowledge to m ... more
Plasticell has licensed EMD Millipore to distribute a superior, single-application osteogenic medium discovered using the combinatorial screening system, CombiCult®.The osteogenic medium is serum- and xeno- free, more consistent and more potent than currently available formulations. Under t ... more
Plasticell announced that patents for its combinatorial cell culture platform technology, CombiCult™, have been granted in the USA and Japan. Patents covering CombiCult™ have now been issued in Europe, USA, Japan, Australia and Singapore.“Plasticell's proprietary technology breaks the maj ... more
Plasticell Ltd has announced today that following its recent £3.5m financing, it has undergone a strategic re-structuring to enable the Company to focus on its award winning CombiCult™ technology for stem cell differentiation. Consequently, Plasticell Ltd has demerged its regenerative drug ... more
Plasticell is a mature biotech company focusing on the development of small molecule drugs that act on progenitor cells, for use in regenerative medicine. Plasticell is able to identify molecules that encourage progenitor cells to differentiate, potentially allowing for the development of ... more