Molecular Mechanics

News Molecular Mechanics

• Nanoneedle is small in size, but huge in applications

  Researchers at the University of Illinois have developed a membrane-penetrating nanoneedle for the targeted delivery of one or more molecules into the cytoplasm or the nucleus of living cells. In addition to ferrying tiny amounts of cargo, the nanoneedle can also be used as an electrochemical probe more

• Fujitsu Develops World's Fastest Method of Quantum Chemical Calculations for Drug Discovery

  Fujitsu Limited and Tokai University's School of Medicine announced the successful validation of the new computational method of quantum chemical calculations for drug discovery. The feasibility of the new method was validated and successfully proved by reproducing the biological activities of sever more

Publications Molecular Mechanics

• Increased levels of phosphoinositides cause neurodegeneration in a Drosophila model of amyotrophic lateral sclerosis

  The Vesicle-associated membrane protein (VAMP)-Associated Protein B (VAPB) is the causative gene of amyotrophic lateral sclerosis 8 (ALS8) in humans. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective death of motor neurons leading to spasticit more

• Subnormal levels of POL{gamma}A cause inefficient initiation of light-strand DNA synthesis and lead to mitochondrial DNA deletions and autosomal dominant progressive external o ...

  The POLG1 gene encodes the catalytic subunit of mitochondrial DNA (mtDNA) polymerase (POL). We here describe a sibling pair with adult-onset progressive external ophthalmoplegia, cognitive impairment and mitochondrial myopathy characterized by DNA depletion and multiple mtDNA deletions. The phenot more

• KBP–cytoskeleton interactions underlie developmental anomalies in Goldberg–Shprintzen syndrome

  Goldberg–Shprintzen syndrome (GOSHS, MIM #609460) is an autosomal recessive disorder of intellectual disability, specific facial gestalt and Hirschsprung's disease (HSCR). In 2005, homozygosity mapping in a large consanguineous family identified KIAA1279 as the disease-causing gene. KIAA1279 encode more

Market studies Molecular Mechanics

• Stakeholder Opinions: Traumatic Brain Injury Hormonal therapy generates optimism

  Introduction There remains no approved pharmacological or cellular treatment to improve the outcome of survivors of traumatic brain injury (TBI). In the past two decades, understanding of the cellular and molecular mechanisms that occur after TBI has grown and a combination of novel therapeutic str more

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