Mitochondria

News Mitochondria

• New light shed on early stage Alzheimer's disease
  

  The disrupted metabolism of sugar, fat and calcium is part of the process that causes the death of neurons in Alzheimer's disease. Researchers from Karolinska Institutet have now shown, for the first time, how important parts of the nerve cell that are involved in the cell's energy metabolism operat more

• Mitochondrial metabolic regulator SIRT4 guards against DNA damage

  Healthy cells don't just happen. As they grow and divide, they need checks and balances to ensure they function properly while adapting to changing conditions around them. Researchers studying a set of proteins that regulate physiology, caloric restriction and aging have discovered another important more

• Blocking cell distress signals can ease autism symptoms

  Autism Speaks announced a study supported by one of Autism Speaks' first Suzanne and Bob Wright Trailblazer Awards, presents a new theory that autism may result from chronic danger signaling by mitochondria, cell structures that supply our cells with energy. This study by Trailblazer researcher and more

White papers Mitochondria

• Altered Expression of Broad Range of Protease Genes in SH-SY5Y Neuroblastoma Cells after Bortezomib Exposure
  

  Neuroblastoma cell lines can be models for the responsiveness of neuroblastomas to chemotherapy-induced cell death as well as for the sensitivity of untransformed neuro-nal cells to toxic side-effects of chemotherapy. Both phenom-ena are relevant to neuroblastoma cells exposed to bortezomib, a proteasome inhibitor in clinical use. It has been shown previously that neuroblastoma cell lines are prone to undergo apoptosis when treated with bortezomib, but the precise molecular mechanism has not been revealed. In addition to this, peripheral neuropathy is the main side effect of chemotherapy that includes bortezomib more

• Membrane Fluidity Measurements Using UV Fluorescence Polarization and the POLARstar Omega
  

  The POLARstar Omega microplate reader from BMG LABTECH was used to study membrane fluidity via fluorescence polarization in 96-well format. The method allows for the monitoring of large scale alterations in membrane fluidity (such as phase transitions), as well as more subtle changes in lipid dynamic. The change in polarization caused by dibucaine and propranolol were investigated in both liposomes and mitochondrial membranes more

Publications Mitochondria

• TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication

  Replication of the mammalian mitochondrial DNA (mtDNA) is dependent on the minimal replisome, consisting of the heterotrimeric mtDNA polymerase (POLG), the hexameric DNA helicase TWINKLE and the tetrameric single-stranded DNA-binding protein (mtSSB). TWINKLE has been shown to unwind DNA during the more

• AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease

  Parkin E3 ubiquitin-ligase activity and its role in mitochondria homeostasis are thought to play a role in Parkinson's disease (PD). We now report that AF-6 is a novel parkin interacting protein that modulates parkin ubiquitin-ligase activity and mitochondrial roles. Parkin interacts with the AF-6 more

• Activating Mutations in Protein Tyrosine Phosphatase Ptpn11 (Shp2) Enhance Reactive Oxygen Species Production That Contributes to Myeloproliferative Disorder

  by Dan Xu, Hong Zheng, Wen-Mei Yu, Cheng-Kui Qu Gain of function (GOF) mutations in protein tyrosine phosphatase Ptpn11 have been identified in childhood leukemias, and these mutations are sufficient to drive the development of myeloproliferative disorder and malignant leukemias in mice. However, more

Market studies Mitochondria

• MitoPharm Corporation - Strategic SWOT Analysis Review

  Mitopharm Corporation (MTPM) is a pharmaceutical company. The company engages in the research, development, marketing and sales of dietary supplements, functional beverages and drugs. The company utilizes the latest technologies in biochemistry, pharmacology and Traditional Chinese Medicinal formula more

Websites Mitochondria