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News Max-Planck-Institut

• Mildew-resistant and infertile

  Mildew infections not only cause unsightly vegetable patches, they can also result in extensive crop failure. Interestingly, the processes involved in infections with this garden pest are similar to those involved in fertilisation. Scientists from the Max Planck Institute for Plant Breeding Research more

• Cornell: Project aims to sequence 2,500 genomes

  Cornell researchers are part of an international collaboration to build the most detailed map of human genetic variation. The map promises to provide a much more comprehensive understanding of the role of inherited DNA variation in human history, evolution and disease and the best methods to use to more

• Cooperation in diabetes research

  The Max Planck Institute (MPI) of Biochemistry in Martinsried and pharmaceutical company GlaxoSmithKline GmbH & Co. KG (GSK) have signed a research agreement on the development of new drugs for the treatment of type II diabetes. The cooperation agreement, negotiated with the help of technology trans more

White papers Max-Planck-Institut

• High-Throughput Cardiac Gene Expression Analysis Using the Universal ProbeLibrary and the Novel LightCycler® 1536 Real-Time PCR System
  

  Although congenital heart malformations are the most common birth defects in humans, the underlying patho­mechanisms remain widely unknown. Through linkage analyzes and candidate-gene approaches, several gene mutations causing congenital heart defects (e.g., CITED2, GATA4, NKX2-5) have been identified. However, most heart malformations display variable expressivity and pene­trance, which indicates a multifactorial and multigenic basis. This suggests that the regulatory context of transcription factors plays an important role in the manifestation of the defects. In order to better understand the molecular pathways in cardiogenesis and disease we studied the global genetic network that is deregulated in malformed hearts more

• New Standard in Electrophysiology and Deep Tissue Imaging
  

  The function of nerve and muscle cells relies on ionic currents flowing through ion channels. These ion channels play a major role in cell physiology. One way to investigate ion channels is to use patch clamping. This method allows investigation of ion channels in detail and recording of the electric activity of different types of cells, mainly excitable cells like neurons, muscle fibres or beta cells of the pancreas. The patch clamping technique was developed by Erwin Neher and Bert Sakmann in the 1970s and 80s to study individual ion channels in living cells. In 1991 they received the Nobel Prize for Physiology and Medicine for their work. Today the patch clamping technique is one of the most important methods in the field of electrophysiology more

Publications Max-Planck-Institut

• Epigenetics [Core Concepts]

  pnas;110/9/3209/UNFIG01F1unfig01This image shows a DNA molecule that is methylated on both strands on the center cytosine. DNA methylation plays an important role for epigenetic gene regulation in development and cancer. Image courtesy Christoph Bock, Max Planck Institute for Informatics.Despite the more

• [News of the Week] Newsmakers

  This week's Newsmakers are MIT neurobiologist Edward Boyden, who received the inaugural A. F. Harvey Engineering Research Prize, and Matthias Mann of the Max Planck Institute of Biochemistry, who has won the 2012 Körber European Science Prize. more

• [News of the Week] Newsmakers

  This week's Newsmakers are Stephen Quake of Stanford University, who has won the Lemelson-MIT Prize; David Jewitt of UCLA, Jane Luu of MIT, Franz-Ulrich Hartl of the Max Planck Institute of Biochemistry, Arthur Horwich of Yale University, and Maxim Kontsevich of the Institute for Advanced Scientific more

Market studies Max-Planck-Institut

• Servizi Italia S.p.A. (SRI) - Financial and Strategic SWOT Analysis Review

  Servizi Italia S.p.A. (Servizi Italia) is a conglomerate company principally engaged in the operations of design, construction and installation of laundries. The services offered by the company include wash-hire services, linen sterilization and sterilization of surgical instruments for public and p more

• MATERNUS Kliniken AG (MAK) - Financial and Strategic SWOT Analysis Review

  MATERNUS Kliniken AG (MATERNUS) is a German based company involved in the operations of care centers for senior citizens and long-term patients, rehabilitation centers and other healthcare facilities. The company owns 23 healthcare centres nationwide. Through its senior and elder care facilities, th more

• RNAi for Therapeutic Applications: Market Prospects 2011-2021

  How will the RNA interference (RNAi) therapies market develop this decade? Our new report shows you that emerging market's revenue potential from 2011 to 2021. You will see the commercial prospects for RNAi-based therapeutics. We aim to save you time and aid your decisions through our research, dat more

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