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UltiMate 3000 XRS systems optimize performance of small particle UHPLC columns, handle pressures up to 1250 bar and offer seamless LC/MS integration more
Is your current HPLC system limiting you? Do you want more sensitivity and confidence in your data than with UV detection? This offer is for you! more
The AxION 2 TOF MS delivers the ideal combination of mass accuracy, dynamic range, speed and sensitivity to optimize performance for any application more
Get the instrument you need without waiting for an investment budget! From 1 to 60 months, from one module to a complete system, whether to react on more
With its new SPECTRO MS ICP mass spectrometer SPECTRO demonstrates that even with the high level of technology today, quantum leaps in development are possible; bringing measurable advantages to users everywhere. The SPECTRO MS is the only commercially available ICP mass spectrometer to offer fully more
Clinical pharmacologists at Heidelberg University Hospital have achieved major progress for improving the reliability of drugs. In a pharmacological study, they showed for the first time that interactions between drugs can be detected with minute doses in the range of nanograms. However, at these lo more
Researchers at the University of Wisconsin-Madison have found a new way to accelerate a workhorse instrument that identifies proteins. The high-speed technique could help diagnose cancer sooner and point to new drugs for treating a wide range of conditions.Proteins are not only numerous — humans hav more
The carcinogenic harmful substance benzene can seriously impact the soil and ground water following chemical accidents or at old industrial sites. Nevertheless, bacteria exist which can degrade this compound even in the absence of oxygen. Until now it was not clear which organisms take part in this more
The ESI-TOF mass spectrometers micrOTOF and micrOTOF focus do not only provide accurate mass measurements but additionally describe the True Isotopic Pattern TIPTM. For molecular formula generation this unique combination significantly reduces the number of possible formula candidates and the elemental composition of compounds with molecular weights far higher than 500 Da can unequivocally be determined more
1st July 2006 is an important deadline for the electro- and electronics industries. This date bans hazardous substances like lead, cadmium, mercury, hexavalent chromium and polybrominated biphenyls and diphenyl ethers from electro- and electronic equipment. This restriction, even though in discussion since 1991, has become more and more important from year to year because of tons of electronic waste releasing toxic substances which are accumulated in the environment, the food chain and all human beings. In order to enforce the substances ban and the limitation or substitution of hazardous components, elemental analysis is obviously the most important control measure for monitoring limiting values. This requires precise analytical systems such as X-ray fluorescence, ICP- and atomic absorption spectrometers. These instruments are able to detect trace concentrations of hazardous compounds - for example cadmium, using an atomic absorption spectrometer in the flame atomization mode up to 0.1 mg/L, or using the di more
ABSTRACT Complementary and alternative medicines (CAM) can affect the pharmacokinetics of anticancer drugs by interacting with the metabolizing enzyme cytochrome P450 (CYP) 3A4. To evaluate changes in the activity of CYP3A4 in patients, levels of 1‐hydroxymidazolam in plasma are often determined more
15‐deoxy‐delta12,14‐prostaglandin J2 (15d‐PGJ2) is an endogenous anti‐inflammatory lipid derived from PGD2. One potential mechanism for its activity is the covalent modification of cellular proteins, via a reactive α,β‐unsaturated carbonyl group in its cyclopentenone ring, which in turn alters pro more
A modified multidimensional protein identification technology (MudPIT) separation was coupled to an LTQ Orbitrap Velos mass spectrometer and used to rapidly identify the near-complete yeast proteome from a whole cell tryptic digest. This modified online two-dimensional liquid chromatography separati more
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